Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-11-09
1995-12-12
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435968, 435 79, 436504, 436 64, 436804, 436813, 424 157, 424 92, 424 96, G01N 33534, G01N 33574, G01N 3358, A61K 3516
Patent
active
054749042
ABSTRACT:
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP"). The invention also provides a method of treating cancer in a mammal comprising administering to the mammal mCRP in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, or cytokine. The mCRP may be administered to the mammal in a pharmaceutically-acceptable carrier or in liposomes. The invention further provides a method of identifying cancer cells in a mammal using mCRP as an imaging agent.
REFERENCES:
patent: 4444744 (1984-04-01), Goldenberg
patent: 4816402 (1989-03-01), Rosen et al.
patent: 4857314 (1989-08-01), O'Connor et al.
Barna et al., Cancer Research, 47:3959-3963 (1987).
Barna et al., Cancer Research, 44:305-310 (1984).
Barna et al., FASEB J., 2274a (1983).
Barna et al., J. Biol. Resp. Mod., 7:483-487 (1988).
Barna et al., FASEB J., 6:1433a (1992).
Bravo et al., J. Rheumatology, 8:291-294 (1981).
Bray et al., Clin. Immunol. Newsletter, 8:137-140 (1987).
Chu et al., Proc. Amer. Acad. Cancer Res., 28:344a (1987).
Chu et al., Proc. Am. Acad. Cancer Res., 29:371a (1988).
Chu et al., Proc. Am. Acad. Cancer Res., 30:333a (1989).
Chudwin et al., J. Allergy Clin. Immunol., 77:216a (1986).
de Beer et al., J. Immuno. Meth., 50:17-31 (1982).
Deodhar et al., J. Biol. Resp. Modifiers, 1:27-34 (1982).
Deodhar et al., Cleveland Clinic Quarterly, 53:223-234 (1986).
Deodhar et al., Cancer Research, 42:5084-5088 (1982).
Doedhar et al., Proc. Am. Assoc. Cancer Research, 32:404 (1991).
Deodhar et al., FASEB J., 3:831a (1989).
Dixon et al., Scand. J. Rheumatology, 13:39-44 (1984).
Gautam et al., J. Biol. Res. Modifiers, 8:560-569 (1989).
Hawkes et al., Analyt. Biochem., 119:142-47 (1982).
Hornung, Proc. Soc. Exp. Biol. Med., 139:1166-1169 (1972).
Guedson et al., J. Histochem. Cytochem., 27:1131-45 (1981).
Hu et al., Biochem., 25:7834-39 (1986).
Hu et al., J. Biol. Chem., 635: 1500-04 (1988).
Kaplan et al., Meth. Enzymol., 172:393-399 (1989).
Kendall et al., J. Immunol. Meth., 56:329-39 (1983).
Kilpatrick et al., Immunol. Res., 10:43-53 (1991).
Krakoff, CA-A Cancer Journal for Clinicians, 41:264-278 (1991).
Laemmli, Nature, 227:680-685 (1970).
Lei et al., J. Biol. Chem., 260:13377-13383 (1985).
MacDonald et al., Biochim. Biophys. Acta, 1061:297-301 (1991).
Mantzouranis et al., Ped. Res., 18:260a (1984).
McIntosh et al., Cancer Research, 49:1408-1414 (1989).
Oku et al., Biochim. Biophys. Acta, 691:332-340 (1982).
Olson et al., Biochim. Biophys. Acta, 557:9-23 (1979).
Osmand et al., Proc. Natl. Acad. Sciences, U.S.A., 74:739-743 (1977).
Pappas et al., J. Immunol. Meth., 64:205-14 (1983).
Pepys et al., Advances in Immunology, 34:141-212 (1983).
Potempa et al., Inflammation, 12:391-405 (1988).
Potempa et al., Mol. Immunol., 20:1165-1175 (1983).
Potempa et al., Mol. Immunol., 24:531-541 (1987).
Potempa et al., Proc. Amer. Acad. Cancer Res., 28:344a (1987).
Potempa et al., FASEB J., 2:731a (1988).
Potempa et al., Protides Biol. Fluids, 34:287-290 (1986).
Radosevich et al., Cancer Research, 46:5808-5812 (1985).
Rees et al., Fed. Proc., 45:263a (1986).
Rizk et al., Cancer, 58:55-61 (1986).
Samols et al., Biochem. J., 227:759-65 (1985).
Samols et al., Protides Biol. Fluids, 34:263-66 (1986).
Sorenson et al., Experientia, 42:161-162 (1986).
Thomassen et al., FASEB J., 6:1151a (1992).
Thombre et al., Cancer Immunol. Immunother., 16:145-150 (1984).
Tillett and Francis, J. Exp. Med., 52:561-71 (1930).
Vigushin et al., J. Clin. Invest., 91:1351-57 (1993).
Volanakis et al., J. Immunol., 113:9-17 (1974).
Volanakis et al., J. Immunol., 126:1820-1825 (1981).
Walker et al., J. Clin. Path., 37:1022-1026 (1984).
Wang et al., J. Biol. Chem., 257:13610-13615 (1982).
Weiss, Clinical and Experimental Metastasis, 7:127-167 (1989).
Whitehead et al., Biochem. J., 266:283-290 (1990).
Woo et al., J. Biol. Chem., 260:13384-88 (1985).
Wood et al., J. Clin. Invest., 30:616-622 (1951).
Ying et al., J. Immunol., 143:221-28 (1989).
Zahedi et al., Cancer Research, 46:5077-5083 (1986).
Zeller et al., Fed. Proc., 46:1033a (1987).
Shields, M. J., et al., J. Immunol Methods, vol. 141, No. 2, pp. 253-262, 1991.
Anderson Byron E.
Kresl John J.
Potempa Lawrence A.
Parsons Nancy J.
Scheiner Toni R.
LandOfFree
Methods of imaging cancer cells using modified C-reactive protei does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of imaging cancer cells using modified C-reactive protei, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of imaging cancer cells using modified C-reactive protei will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1359203