Methods of identifying transition metal complexes that selective

Details Methods of identifying transition metal complexes that selective Methods of identifying transition metal complexes that selective

1997-04-29

1998-11-10

Marschel, Ardin H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 436501, 514 1, 514183, 514184, 514185, 514188, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C12Q 168

Patent

active

058341994

ABSTRACT:
Methods for selecting transition metal complexes (TMCs) that can modulate the translation of an mRNA by selectively cleaving a regulatory element of the mRNA are described. Included are in vitro, in situ, and/or in vivo methods. In addition, methods of identifying and characterizing mRNAs that contain regulatory elements which can be targeted by the TMCs of the present invention are also provided. Pharmaceutical compositions containing the TMCs of the present invention are also included.

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