Methods of identifying respondents to hypoxia inducible...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007240, C530S387100

Reexamination Certificate

active

07629128

ABSTRACT:
This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates to methods of monitoring a patient response to a given dosage of an HIF inhibitor. The invention also includes assays and kits for performing the methods described herein.

REFERENCES:
patent: 5602278 (1997-02-01), Kirkpatrick
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Makino et al. Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J Immunol. Dec. 15, 2003;171(12):6534-40.
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Powis, et al., Hypoxic inducible factor-1α as a cancer drug test, 2004, Mol. Cancer Ther. 3(5):647-654.
Welsh et al., PX-478—A Potent Inhibitor of Hypoxia-Inducible Factor-1 and Anti-Tumor Agent, Nov. 19-22, 2002, AACR-EORTC-NCI Meeting, Frankfurt, Germany.
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