Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-11-20
2007-11-20
Landsman, Robert S. (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007900, C435S008000, C530S350000
Reexamination Certificate
active
10693164
ABSTRACT:
Described herein are methods of identifying a transmembrane receptor (TMR) agonist and compounds identified by this method. The TMR agonist (TMRA) is capable of activating TMR signaling while exhibiting reduced TMR internalization over a control compound.
REFERENCES:
patent: 5891646 (1999-04-01), Barak et al.
patent: 6110693 (2000-08-01), Barak et al.
patent: 6528271 (2003-03-01), Bohn et al.
patent: 6716588 (2004-04-01), Sammak et al.
patent: 6770449 (2004-08-01), Barak et al.
patent: 6800445 (2004-10-01), Palmer et al.
patent: 2003/0013137 (2003-01-01), Barak et al.
patent: 2003/0049643 (2003-03-01), Barak et al.
patent: 2005/0032125 (2005-02-01), Oakley et al.
patent: WO98/00715 (1998-01-01), None
patent: WO99/66324 (1999-12-01), None
patent: WO 01/46691 (2001-06-01), None
patent: WO 01/46694 (2001-06-01), None
patent: WO 02/46763 (2002-06-01), None
patent: WO 03/097795 (2003-11-01), None
patent: WO 2004/004451 (2004-01-01), None
Ghosh, et al. J. Biomol. Screening 10(5): 476-484, 2005 ‘Quantitative Cell-Based High-Content Screening for Vasopressin Receptor Agonists Using Transfluor Technology’.
Vassilatis, et al. PNAS 100 (8): 4903-4908 ‘The G protein-coupled receptor repertoires of human and mouse’, 2003.
Barak, Larry S., “Internal Trafficking and Surface Mobility of a Functionally Intact B2-Adrenergic Receptor-Green Fluorescent Protein Conjugate”,Molecular Pharmacology, vol. 51, No. 2, pp. 177-184 (Feb. 1997), 177-184.
Bisello, Alessandro ,et al.,“Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations”,The Journal of Biological Chemistry, vol. 277, No. 41, pp. 38524-38530 (Oct. 11, 2002).
Chen, Chongguang ,et al.,“Inverse Agonist Up-Regulates the Constitutively Active D3.49(164)Q Mutant of the Rat m-Opioid Receptor by Stabilizing the Structure and Blocking Constitutive Internalization and Down-Regulation”,Molecular Pharmacology, vol. 60, No. 5, pp. 1064-1065 (Nov. 2001), 1064-1065.
Hanley, Nicole R.,et al.,“Mechanisms of Ligand-Induced Desensitization of the 5-Hydroxytryptamine2A Receptor”,The Journal of Pharmacology and Experimental Therapeutics, vol. 300, No. 2, pp. 468-477 (Feb. 2002),467-477.
Emorine, L., et al., “Molecular characterization of the human β3-adrenergic receptor,”Science245:1118-1121 (Sep. 1989).
Eckhardt Allen E.
Loomis Carson R
Oakley Robert H.
Wang Shuntai
Baba Edward J.
Brezner David J.
Landsman Robert S.
Molecular Devices Corporation
Morgan & Lewis & Bockius, LLP
LandOfFree
Methods of identifying reduced internalization transmembrane... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of identifying reduced internalization transmembrane..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of identifying reduced internalization transmembrane... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3866189