Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-05
2000-08-08
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 6, 435 71, 435501, G01N 3353
Patent
active
061000469
ABSTRACT:
The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
REFERENCES:
Burgess et al, The Journal of Cell Biology, 111: 2129-2138, 1990.
Lazar et al, Molecular and Cellular Biology, 8(3): 1247-1252, 1988.
Boulter James Richard
Elgoyhen Ana Belen
Heinemann Stephen Fox
Johnson David S.
Duffy Patricia A.
Hutzell Paula K.
Reiter Stephen E.
The Salk Institute for Biological Studies
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