Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2011-03-15
2011-03-15
Lin, Jerry (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
Reexamination Certificate
active
07908087
ABSTRACT:
A method of identifying latent splice sites, the method comprising identifying at least one intronic in-frame stop codon located upstream of a 5′ splice site sequence being a latent splice site, thereby identifying latent splice sites.
REFERENCES:
patent: 0264166 (1988-04-01), None
patent: WO 98/38297 (1998-03-01), None
patent: WO 98/38298 (1998-03-01), None
patent: WO 98/38299 (1998-03-01), None
Biotech Life Science Dicationary “locus” (1998) available at http://biotech.icmb.utexas.edu/search/dict-search2.html?bo1=AND&word=locus%20(pl.%20loci)&search—type=normal&def=.
Burge et al. “Prediction of Complete Gene Structures in Human Genomic DNA,” J. Mol. Biol. (1997) vol. 268, pp. 78-94.
Kananura et al. “A Splice-Site Mutation in GABRG2 Associated with Childhood Absence Epilepsy and Febrile Convulsions,” Arch. Neurol. (Jul. 2002) vol. 59, pp. 1137-1141.
Cartegni et al. “Listening to Silence and Understanding Nonsense: Exonic Mutations That Affect Splicing”, Nature Review Genetics, 3(4): 285-298, 2002.
Office Action Dated Oct. 12, 2008 From the Israeli Patent Office Re.: Application No. 163945 and Its Translation Into English.
Office Action Dated Feb. 1, 2010 From the Israel Patent Office Re.: Application No. 163945 and Its Translation Into English.
Louis et al. “Molecular Biology of Central Nervous System Tumors”, http://brain.mgh.havard.edu/MolecularGenetics.htm, 2005.
Black “Protein Diversity From Alternative Slicing: A Challenge for Bioinformatics and Post-Genome Biology”, Cell, vol. 103, pp. 367-370, 2000.
Brudno et al. “Computational Analysis of Candidate Intron Regulatory Elements for Tissue-Specific Alternative Pre-mRNA Splicing”, Nucleic Acids Research, vol. 29(11):2338-2351, XP002248424, ISSN:0305-1048, 2001.
Lopez “Alternative Splicing of Pre-mRNA: Developmental Consequences and Mechanisms of Regulation”, Annu. Rev. Genetics, 32: 279-305, 1998.
Ahn et al. “The Structural and Functional Diversityof Dystrophin”, Nature Genetics, 3: 283-291, 1993.
Aoufouchi et al. “Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis”, Cell, 85: 415-422, 1996.
Bach et al. “Molecular Analysis of Hurler Syndrome in Druze and Muslim Arab Patients in Israel: Multiple Allelic Mutations of the IDUA Gene in A Small Geographic Area”, Am. J. Hum. Genet., 53: 330-338, 1993.
Banerji et al. “A Lymphocyte-Specific Cellular Enhancer Is Located Downstream of the Joining Region in Immunoglobulin Heavy Chain Genes”, Cell, 33: 729-740, 1983.
Bedwell et al. “Suppression of A CFTR Premature Stop Mutation in A Bronchial Epithelial Cell Line”, Nature Medicine, 3(11): 1280-1284, 1997.
Berget “Exon Recognition in Vertebrate Splicing”, The Journal of Biological Chemistry, 270(6): 2411-2414, 1995.
Black “Finding Splice Sites Within A Wilderness of RNA”, RNA, 1: 763-771, 1995.
Blencowe “Exonic Splicing Enhancers: Mechanism of Action, Diversity and Role in Human Genetic Diseases”, Trends Biochem. Sci., 25: 106-110, 2000.
Buckbinder et al. “Gene Regulation by Temperature-Sensitive P53 Mutants: Identification of P53 Response Genes”, Proc. Natl. Acad. Sci. USA, 9.1: 10640-10644, 1994.
Byrne et al. “Multiplex Gene Regulation: A Two-Tiered Approach to Transgene Regulation in Transgenic Mice”, Proc. Natl. Acad. Sci. USA, 86: 5473-5477, 1989.
Calame et al. “Transcriptional Controlling Elements in the Immunoglobulin and T Cell Receptor Loci”, Advances in Immunology, 43: 235-275, 1988.
Carter et al. “A Regulatory Mechanism That Detects Premature Nonsense Codons in T-Cell Receptor Transcripts In Vivo Is Reversed by Protein Synthesis Inhibitors In Vitro”, The Journal of Biological Chemistry, 270(48): 28995-29003, 1995.
Charlet-B. et al. “Loss of the Muscle-Specific Chloride Channel in Type 1 Myotonic Dystrophy Due to Misregulated Alternative Splicing”, Molecular Cell, 10: 45-53, 2002.
Cole et al. “Human Monoclonal Antibodies”, Molecular and Cellular Biochemistry, 62: 109-120, 1984.
Cote et al. “Generation of Human Monoclonal Antibodies Reactive With Cellular Antigens”, Proc. Natl. Acad. Sci. USA, 80: 2026-2030, 1983.
Culbertson “RNA Surveillance: Unforeseen Consequences for Gene Expression, Inherited Genetic Disorders and Cancer”, Trends in Genetics, 15(2); 74-80, 1999.
Dietz et al. “The Skipping of Constitutive Exons In Vivo Induced by Nonsense Mutations”, Science, 259(5095): 680-683, 1993.
Dietz et al. “Maintenance of An Open Reading Frame as An Additional Level of Scrutiny During Splice Site Selection”, Nature Genetics, 8: 183-188, 1994.
Dostie et al. “Nuclear Eukaryotic Initiation Factor 4E(eIF4E) Colocalizes With Splicing Factors in Speckles”, The Journal of Cell Biology, 148: 239-247, 2000.
Dumas et al. “New Species of Human Tyrosine Hydroxylase mRNA Are Produced in Variable Amounts in Adrenal Medulla and Are Overexpressed in Progressive Supranuclear Palsy”, Journal of Neurochemistry, 67: 19-25, 1996.
Edlund et al. “Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5$img id="CUSTOM-CHARACTER-00001" he="2.79mm" wi="2.79mm" file="US07908087-20110315-P00001.TIF" alt="custom character" img-content="character" img-format="tif" ?{\Prime}$ Flanking Elements”, Science, 230(4728): 912-916, 1985.
Fairbrother et al. “Predictive Identification of Exonic Splicing Enhancers in Human Genes”, Science, 297: 1007-1013, 2002.
Farnham et al. “Characterization of the 5′ End of the Growth-Regulated Syrian Hamster CAD Gene1”, Cell Growth & Differentiation, 1: 179-189, 1990.
Fodor et al. “Light-Directed, Spatially Addressable Parallel Chemical Synthesis”, Science, 251(4995): 767-773, 1991.
Frischmeyer et al. “Nonsense-Mediated mRNA Decay in Health and Disease”, Human Molecular Genetics, 8(10): 1893-1900, 1999.
Fu “The Superfamily of Arginine/Serine-Rich Splicing Factors”, RNA, 1: 663-680, 1995.
Gersappe et al. “A Premature Termination Codon in Either Exon of Minute Virus of Mice P4 Promoter-Generated Pre-mRNA Can Inhibit Nuclear Splicing of the Intervening Intron in an Open Reading Frame-Dependent Manner”, The Journal of Biological Chemistry, 274(32): 22452-22458, 1999.
Graveley “Sorting Out the Complexity of SR Protein Functions”, RNA, 6: 1197-1211, 2000.
Green “Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing”, Annu. Rev. Cell Biol., 7: 559-599, 1991.
Grima et al. “A Single Human Gene Encoding Multiple Tyrosine Hydroxylases With Different Predicted Functional Characteristics”, Nature, 326: 707-711, 1987.
Hammond et al. “Angiogenic Gene Therapy for Heart Disease: A Review of Animal Studies and Clinical Trials”, Cardiovascular Research, 49: 561-567, 1987.
Hentze et al. “A Perfect Message: RNA Surveillance and Nonsense-Mediated Decay”, Cell, 96: 307-310, 1999.
High “Gene Therapy: A 2001 Perspective”, Haemophilia, 7(Suppl.1): 23-27, 2001.
Howard et al. “Aminoglycoside Antibiotics Restore CFTR Function by Overcoming Premature Stop Mutations”, Nature Medicine, 2(4): 467-469, 1996.
Iborra et al. “Coupled Transcription and Translation Within Nuclei of Mammalian Cells”, Science, 293: 1139-1142, 2001.
International Human Genome Sequencing Consortium “Initial Sequenciong and Analysis of the Human Genome”, Nature, 409: 860-921, 2001.
Isner “Myocardialgenetherapy”, Nature, 415: 234-239, 2002.
Kohler et al. “Continuous Cultures of Fused Cells Secreting antibody of Predefined Specificity”, Nature, 256: 495-497, 1975.
Kozbor et al. “Specific Immunoglob
Sperling Joseph
Sperling Ruth
Lin Jerry
Yeda Research and Development Co. Ltd.
Yissum Research Development Company of the Hebrew University of
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