Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1998-03-19
2000-06-20
Nashed, Nashaat
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435194, 436 86, 530300, 530350, C12Q 148, G01N 3300
Patent
active
06077682&
ABSTRACT:
The present invention provides N-terminal truncated transmembrane sensor histidine kinases that retain their ability to be autophophorylated and/or their related histidine kinase activity. The N-terminal truncated transmembrane sensor histidine kinases are useful for obtaining detailed three-dimensional structural data of the catalytic portion of the protein. The three-dimensional structural data is included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the N-terminal truncated transmembrane sensor histidine kinases are also provided.
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Ikura Mitsuhiko
Inouye Masayori
Park Heiyoung
Nashed Nashaat
Ontario Cancer Institute
University of Medicine and Dentistry of New Jersey
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