Methods of identifying inhibitors of sensor histidine kinases th

Details Methods of identifying inhibitors of sensor histidine kinases th Methods of identifying inhibitors of sensor histidine kinases th

1998-09-23

2000-12-19

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

530350, 530324, 4352523, 4353201, 435325, C12N 912, C12N 120, C12N 1500, C12N 500, C07K 100

Patent

active

061626279

ABSTRACT:
The present invention provides N-terminal truncated transmembrane sensor histidine kinases that retain their ability to be autophosphorylated and/or their related histidine kinase activity. The N-terminal truncated transmembrane sensor histidine kinases are useful for obtaining detailed three-dimensional structural data of the catalytic portion of the protein. The three-dimensional structural data is included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the N-terminal truncated transmembrane sensor histidine kinases are also provided.

REFERENCES:
Alex et al, 1996, Proc Natl Acad Sci USA, 99:3416-21.
Alexandrov et al., 1992, J Mol Biol 225:5-9.
Altschul et al, 1997, Nucleic Acids Res, 25:3389-402.
Altschul et al., 1990, J Mol Biol, 215:403-10.
Appleby et al., 1996, Cell. 86:845-8.
Bagby et al, 1995, Cell, 82:857-67.
Bagby et al., 1994, Biochem, 33:2409-21.
Barrett et al., 1998, Proc Natl Acad Sci USA, 95:5317-22.
Baumgartner et al., 1994, J Bacteriol, 176:1157-63.
Chang et al., 1993, Science, 262:539-44.
Delgado et al., 1993 Mol Microbiol. 10:1037-47.
Dutta et al, 1996, J Biol Chem, 271:1424-9.
Egger et al., 1997, Gen Cell, 2:167-84.
Gardina et al., 1996, Science, 274:425-6.
Gill et al., 1989, Analytical Biochem. 182:319-26.
Hidaka et al., 1997, FEBS Lett, 400:238-42.
Holdgate et al., 1997, Biochemistry, 36:9663-73.
Igo et al., 1989, Gen Dev, 3:1725-34.
Kraulis, 1991, J. Appl. Cryst. 24:946-959.
Munoz-Dorado et al., 1993, J Cell Biochem, 51:29-33.
Ota et al., 1993, Science, 262:566-9.
Pan et al., 1993, Proc Natl. Acad Sci USA, 90:9939-43.
Park et al., 1997, J Bacteriol, 179:4382-90.
Parkinson et al., 1992, An Rev. Gen, 26:71-112.
Prodromou et al., 1997, Cell, 90:65-76.
Roberts et al., 1994, J Biol Chem, 269:8728-33.
Sicheri et al., 1997, Nature, 385:602-9.
Soncini et al., 1996, J Bacteriol. 178:6796-801.
Stock et al., 1989, Microbiol Rev, 53:450-90.
Swanson et al., 1993, Mol Microbiol, 8:435-41.
Swanson et al., 1993, Biochem, 32:7623-9.
Surette et al., 1996, J Biol Chem, 271:939-45.
Tatsuno et al., 1996, Science, 274:423-5.
Uhl et al., 1996, EMBO J, 15:1028-36.
Utsumi et al., 1989, Science, 245:1246-9.
Wigley et al., 1991, Nature, 351:624-9.
Yang et al., 1993, J Mol Biol 232:493-8.
Yang et al., 1991, Proc Natl Acad Sci USA, 88:11057-61.
Yang et al., 1993, J Mol Biol, 231:335-42.
Yoshida et al., 1993, Biochemistry 32:2162-66.
Comeau et al., J. bacteriol., 164(2), 578-584, Aug. 1985.
Roberts et al., J.B.C., 269(12), 8728-8733, Mar. 1994.

Affiliated with

Also associated with

Rating

Methods of identifying inhibitors of sensor histidine kinases th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of identifying inhibitors of sensor histidine kinases th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of identifying inhibitors of sensor histidine kinases th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-270248