Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-10-24
2006-10-24
Chism, B. Dell (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C514S013800, C514S015800, C514S016700, C530S329000, C530S324000, C530S326000, C530S327000, C530S328000
Reexamination Certificate
active
07125850
ABSTRACT:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
REFERENCES:
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Richards, S.A. et al., “The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC, RAN-GAP and HTF9A/RANBP1,”Journal of Biological Chemistry, 1995, pp. 14405-14411, vol. 270(24).
Smith, M.L. et al., “Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation of cisplatin,”Oncogene, 1996, pp. 2255-2263, vol. 13.
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Yang, Q. et al., “Mechanisms of a GADD45-mediated G2/M checkpoint,” AACR special conference, Genetic and Functional Consequences of Cell Cycle Alteration in Cancer, Oct. 20-24, 1999, San Diego, California, USA.
Zhan, Q. et al., “Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45,”Oncogene, 1999, pp. 2892-2900, vol. 18.
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Coursen Jill D.
Fornace, Jr. Albert J.
Harris Curtis C.
Wang Xin Wei
Zhan Qimin
Chism B. Dell
The United States of America as represented by the Department of
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