Methods of identifying human osteoclast-specific and related gen

Details Methods of identifying human osteoclast-specific and related gen Methods of identifying human osteoclast-specific and related gen

1995-06-01

1997-04-29

Zitomer, Stephanie

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352523, 4353701, 536 231, C07H 2102, C07H 2104, C12Q 168

Patent

active

056248016

ABSTRACT:
The present invention relates to a method of identifying DNA encoding an osteoclast-specific or -related gene product. The method comprises hybridizing DNA with a stromal cell+, osteoclast+probe, or with cDNA or mRNA from an osteoclastoma, and with a stromal cell+, osteoclast-probe, or with cDNA or mRNA from stromal cells; and identifying DNA which hybridizes to the stromal cell+, osteoclast+probe, or to cDNA or mRNA from osteoclastoma, but not to the stromal cell+, osteoclast-probe, or to cDNA or mRNA from stromal cells.

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Ek-Rylander, B. et al., "Cloning, Sequence, and Developmental Expression of a Type 5, Tartrate-Resistant, Acid Phosphatase of Rat Bone," The J. Biological Chem., 266:24684-24689 (Dec. 25, 1991).
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