Methods of identifying compounds that upmodulate T cell...

Details Methods of identifying compounds that upmodulate T cell... Methods of identifying compounds that upmodulate T cell...

2001-06-28

2008-10-07

Ouspenski, Ilia (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

Reexamination Certificate

active

07432059

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. The invention further provides methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1-mediated signal. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 5698520 (1997-12-01), Honjo et al.
patent: WO 01/14557 (2001-03-01), None
patent: WO 01/39722 (2001-06-01), None
patent: WO 01/39722 (2001-06-01), None
patent: WO 01/83750 (2001-11-01), None
patent: WO 01/83750 (2001-11-01), None
patent: WO 01/94413 (2001-12-01), None
patent: WO 01/94413 (2001-12-01), None
patent: WO 02/00730 (2002-01-01), None
patent: WO 02/08279 (2002-01-01), None
patent: WO 02/08279 (2002-01-01), None
Greenwald et al. Cur. Opin. Immunol. 2002; 14:391-396.
Ishida, Y. et al. “Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death,” EMBO J. Nov. 1992;11(11):3887-95.
Krummel, M.F. et al. “CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells,” J. Exp. Med. Jun. 1, 1996;183(6):2533-40.
Nishimura, H. et al. “Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes,” Int. Immunol. May 1996;8(5):773-80.
Nishimura, H. et al. “Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses,” Int. Immunol. Oct. 1998;10(10):1563-72.
Shinohara, T. et al. “Structure and chromosomal localization of the human PD-1 gene (PDCD1),” Genomics Oct. 1994;23(3):704-6.
Walunas, T.L. et al. “CTLA-4 ligation blocks CD28-dependent T cell activation,” J. Exp. Med. Jun. 1, 1996;183(6):2541-50.
Agata et al. “Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.”Int. Immunol. May 1996;8(5):765-72.
Dong et al. “B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.”Nat. Med. Dec. 1999;5(12):1365-9.
Freeman et al. “The B7-homologue, PD-L is the ligand of the PD-1 immunoinhibitory receptor,”FASEB J. Apr. 20, 2000;14(6):A913.
Freeman et al. “Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.”J. Exp. Med. Oct. 2, 2000;192(7):1027-34.
Latchman et al. “PD-L2 is a second ligand for PD-1 and inhibits T cell activation.”Nat. Immunol. Mar. 2001;2(3):261-8.
Tseng et al. “B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.”J. Exp. Med. Apr. 2, 2001;193(7):839-45.

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