Combinatorial chemistry technology: method – library – apparatus – Method of screening a library – By measuring the effect on a living organism – tissue – or cell
Reexamination Certificate
2011-05-10
2011-05-10
Lundgren, Jeffrey S. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of screening a library
By measuring the effect on a living organism, tissue, or cell
C435S006120
Reexamination Certificate
active
07939468
ABSTRACT:
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.
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Minvielle-Sebastia, L. & Keller, W.,
Boesen Christian
Jones Day
Lundgren Jeffrey S.
PTC Therapeutics, Inc.
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