Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-27
2008-05-27
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07378251
ABSTRACT:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
REFERENCES:
patent: 5831049 (1998-11-01), Hillman et al.
patent: 5958707 (1999-09-01), de Vries et al.
patent: 6689775 (2004-02-01), Powis
Chen X. et al., Crystallization and preliminary X-ray analysis of a Trx domain of human thioredoxin-like protein, ACTA Cryst. D57:1712-1714 (2001).
Lee K. et al., Purification, Molecular Cloning, and Characterization of TRP32, a Novel Thioredoxin-related Mammalian Protein of 32 kDa, The Journal of Biological Chemistry 273:30:19160-19166 (1998).
Miranda-Vizuete et al., Molecular Cloning and Expression of a cDNA Encoding a Human Thioredoxin-like Protein, Biochemical and Biophysical Research Communications 243:284-288 (1998).
Miranda-Vizuete et al., Identification of a Novel Thioredoxin-I Pseudogene on Human Chromosome 10, DNA Sequence 10(6):411-414 (2000).
Miranda-Vizuete et al., Genomic Structure and Chromosomal Localization of Human Thioredoxin-Like Protein Gene (txl) DNA Sequence 10(6): 419-424 (2000).
Miranda et al., 2000, Genomic Structure and Chromosomal Localization of Human Thioredoxin-Like Protein Gene (txl),DNA Sequence10(6):419-424.
Databases Unisave, “Thioredoxin-like protein (32kDa thoredoxin-like protein),” Accession No. 043396 (Jun. 6, 2002).
Anderson David C.
Bennett Mark K.
Kinoshita Taisei
Kinsella Todd M.
Masuda Esteban
Diehl James J.
Francis Carol L.
Keddie James S.
Pak Michael
Rigel Pharmaceuticals Inc.
LandOfFree
Methods of identifying compounds that modulate IL-4... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of identifying compounds that modulate IL-4..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of identifying compounds that modulate IL-4... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2783456