Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-09-03
1998-11-17
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 701, 435 711, 435 712, 435965, 436547, C12Q 168, G01N 3353
Patent
active
058374604
ABSTRACT:
A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.
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Diede
Kieber-Emmons Thomas
Von Feldt Joan M.
Weiner David B.
Williams William V.
Allen Marianne P.
Duffy Patricia A.
The Wistar Institute
Trustees of the University of Pennsylvania
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