Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2009-04-22
2010-12-07
Shafer, Shulamith H. (Department: 1647)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
C436S512000, C435S007100, C435S007200, C435S007210
Reexamination Certificate
active
07846744
ABSTRACT:
A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune disorders. The identification of a DC-SIGN receptor type which interacts with IgG to promote a biological response reducing inflammation associated with immune disorders provides for methods of screening and selecting compounds which may be useful in treating various immune disorders by acting to modulate a DC-SIGN(+)cell to signal a second effector macrophage, causing an increase in expression of the FcγRIIB receptor and in turn inhibiting a cellular-mediated inflammatory response.
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Anthony Robert M
Ravetch Jeffrey V.
Fox Rothschild LLP
Norton Gerard P.
Shafer Shulamith H.
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