Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-05-02
2009-11-24
Bertoglio, Valarie (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S029000, C435S455000
Reexamination Certificate
active
07622255
ABSTRACT:
Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against hematopoietic tumors, i.e. leukemia and lymphoma cells, which may include screening assays directed at β-catenin, or members of the β-catenin signaling pathway. Cellular proliferation in hematopoietic cells can be altered by introducing stabilized β-catenin into a hematopoietic cell that is altered in its ability to undergo apoptosis but which is not fully transformed. The immortalized cells are useful in screening assays, and in the analysis of pathways by which hematopoietic cells undergo transformation.
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Ailles Laurie
Jamieson Catriona Helen M.
Reya Tannishtha
Weissman Irving L.
Bertoglio Valarie
Bozicevic Field & Francis LLP
Montanari David
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
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