Methods of identifying agonists and antagonists of hTASR...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C435S029000

Reexamination Certificate

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08043823

ABSTRACT:
The present invention relates to agonists of the human bitter-taste receptors hTAS2R46, hTAS2R47 and hTAS2R50 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R46, hTAS2R47 and hTAS2R50 bitter taste transduction or bitter taste response.

REFERENCES:
patent: 7413867 (2008-08-01), Bufe et al.
patent: 2008/0187936 (2008-08-01), Li et al.
patent: 03006482 (2003-01-01), None
patent: 2004029087 (2004-04-01), None
patent: 2006086150 (2006-08-01), None
Caicedo et al., “Taste Receptor Cells That Discriminate Between Bitter Stimuli,” Science, Feb. 23, 2001, pp. 1557-1560, vol. 291.
Dulac, Catherine, “The Physiology of Taste, Vintage 2000,” Cell, Mar. 17, 2000, pp. 607-610, vol. 100, Cambridge, Massachusetts, Cell Press.
Kinnamon,Sue, “A Plethora of Taste Receptors,” Neuron, Mar. 2000, pp. 507-510, vol. 25, Colorado, Cell Press.
Lindemann, Bernd, “Receptors and transduction in taste,” Nature, Sep. 13, 2001, pp. 219-225, vol. 413, Mcmillan Mgazines Ltd.
Margolskee, Robert F., “Molecular Mechanisms of Bitter and Sweet Taste Transduction,” The Journal of Biological Chemistry, pp. 1-4, col. 277, No. 1, Jan. 4, 2002, The American Society for Biochemistry and Molecular Biology, Inc.
Chandrashekar et al., “T2Rs Function as Bitter Taste Receptors,” Cell, Mar. 17, 2000, pp. 703-711, vol. 100, Cell Press.
Matsunami et al., “A family of candidate taste receptors in human and mouse,” Nature, Apr. 6, 2000, pp. 601-604, vol. 404, Mcmillan Mgazines Ltd.
Adler et al., “A Novel Family of Mammalian Taste Receptors,” Cell, Mar. 17, 2000, pp. 693-702, vol. 100, Cell Press.
Bufe et al., “The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides,” Nature Genetics, Nov. 2002, pp. 397-401, vol. 32, Nature Publishing Group.
McClintock, et al., “Functional Expression of Recombinant G-Protein-Coupled Receptors Monitored by Video Imaging of Pigment Movement in Melanophores,” Analytical Biochemistry, 1993, pp. 298-305, vol. 209, Academic Press, Inc.
McClintock, et al., “Functional analysis by imaging of melanophore pigment dispersion of chimeric receptors constructed by recombinant polymerase chain reaction,” Brain Research Protocols, 1997, pp. 59-68, Elsevier Science B.V.
Potenza et al., “A Rapid Quantitative Bioassay for Evaluating the Effects of Ligands Upon Receptors That Modulate cAMP Levels in a Melanophore Cell Line,” Pigment Cell Research, 1992, pp. 372-378, vol. 5, Munksgaard.
Potenza et al., “A Method for Evaluating the Effects of Ligands upon Gs Protein-Coupled Receptors Using a Recombinant Melanophore-Based Bioassay,” Analytical Biochemistry, 1992, pp. 315-322, vol. 206, Academic Press, Inc.
Carlezon, et al. “Herpes Simplex Virus-Mediated Gene Transfer As a Tool for Neuropsychiatric Research,” Critical Reviews in Neurobiology, 2000, pp. 47-67, vol. 14(1), Begell House, Inc.
Carter et al., “Adeno-associated viral vectors as gene delivery vehicles (Review),” International Journal of Molecular Medicine, 2000, pp. 17-27.
Kobinger et al., “Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo,” Nature Biotechnology, Mar. 2001, pp. 225-230, vol. 19, Nature Publishing Group.
Lindemann, Bernd, “Sodium taste,” Current Opinion in Nephrology and Hypertension, 1997, pp. 425-429, Rapid Science Publishers.
Springer et al., “VEGF Gene Delivery to Muscle: Potential Role for Vasculogenesis in Adults,” Molecular Cell, Nov. 1998, pp. 549-558, vol. 2, Cell Press.
Wilkie et al., “Characterization of G-protein α subunits in the Gq class: Expression in murine tissues and in stromal and hematopoietic cell lines,” Proc. Natl. Acad. Sci., Nov. 1991, pp. 10049-10053, vol. 88.
Berridge et al., “Inositol trisphosphate, a novel second messenger in cellular signal transduction,” Nature, Nov. 22, 1984, pp. 315-321, vol. 312, Nature Publishing Group.
Behrens et al., “NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression,” European Journal of Neuroscience, 2000, pp. 1372-1384, vol. 12, European Neuroscience Association.
Behrens et al., “Bitter taste receptors and human bitter taste perception,” Cell. Mol. Life Sci., 2006, pp. 1501-1509, vol. 63, Birkhaeuser Verlag.
Maiti et al., “Therapeutic potentials of Andrographolide from Andrographis paniculata: A review,” Journal of Natural Remedies, 2006, pp. 1-13, vol. 6/1.
Govindachari et al., “Antifeedant activity of some diterpenoids,” Fitoterapia, 1999, pp. 269-274, vol. 70, Elsevier Science B.V.
L.-J. Chang et al. “The Molecular Genetics of Lentiviral Vectors—Current and Future Perspectives”, Current Gene Therapy, 2001;1(3): 237-251.
International Search Report for PCT/EP2008/002528, dated Jun. 27, 2008 (6 pages).
Behrens, M et al., “Signaling in the Chemosensory Systems; Bitter taste receptors and human bitter taste perception”, CMLS Cellular and Molecular Life Sciences, Birkäuser-Verlag, BA, vol. 63, No. 13, May 19, 2006 (2006-05029), pp. 1501-1509, XP019419216, ISSN: 1420-9071 (not submitted, document requested).
Maiti, Kuntal et al., “Therapeutic potentials of Andrographolide from Andrographis paniculata: A review”, Journal of Natual Remedies, vol. 6, No. 1, Jan. 2006, pp. 1-13, XP009089564, ISSN: 0972-5547 (not submitted, document requested).
Govindachari, T R et al., “Antifeedant activity of some diterpenoids” FITOTERAPIA, IDB Holding, Milan, IT, vol. 70, No. 3, Jun. 1, 1999, pp. 269-274, XP004829764, ISSN: 0367-326X (not submitted, document requested).

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