Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-24
2007-07-24
Yaen, Christopher H. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
08948124
ABSTRACT:
Methods for identifying agents which enhance the activity of a caspase according to the invention are described, as well as methods for enhancing caspase activity and methods for enhancing apoptosis in a lymphocyte.
REFERENCES:
patent: 5929042 (1999-07-01), Troy et al.
patent: WO 97/10711 (1997-03-01), None
AY3 in PTO-1449 Fearnhead et al.
Gurtu et al Analytical Biochemistry, vol. 251, 98-102, Aug. 15, 1997.
Robertson, Noreen M., et al., “Baculovirus p35 Inhibits the Glucocorticoid-Mediated Pathway of Cell Death”,Cancer Research, 57:43-47 (1997).
Bertrand, Richard., et al., “Induction of a Common Pathway of Apoptosis by Staurosporine”,Experimental Cell Research, 211:314-321 (1994).
Takahashi, A., et al., “CrmA/SPI-2 Inhibition of an Endogenous ICE-related Protease Responsible for Lamin A Cleavage and Apoptotic Nuclear Fragmentation”,The Journal of Biological Chemistry, 271(51) : 32487-32490 (1996).
Xiang, J., et al., “BAX-Induced Cell Death May Not Require Interleukin 1β-Converting Enzyme-Like Proteases”,Proc. Natl. Acad. Sci., 93:14559-14563 (1996).
Takahashi, A., et al., “Inhibition of ICE-Related Proteases (Caspases) and Nuclear Apoptosis by Phenylarsine Oxide”,Experimental Cell Research, 231:123-131 (1997).
Fowlkes and Pardoll, “Molecular and Cellular Events of T Cell Development”,Adv. Immunol., 44:207-264 (1989).
Nossal, “Negative Selection of Lymphocytes”,Cell, 76:229-239 (1994).
Murphy et al., “Induction by Antigen Of Intrathymic Apoptosis of CD4+CD8+TCR10Thymocytes in Vivo”,Science, 250:1720-1723 (1990).
Trauth et al., “Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis”,Science, 245:301-305 (1989).
Yonehara et al., “A Cell-Killing Monoclonal Antibody (ANTI-Fas) to a Cell Surface Antigen Co-Downregulated with the Receptor of Tumor Necrosis Factor”,J. Exp. Med.,169:1747-1756 (1989).
Itoh and Nagata, “A Novel Protein Domain Required for Apoptosis”,J. Biol. Chem., 268(15) :10932-10937 (1993).
Alderson et al., “Regulation of Apoptosis and T Cell Activation by Fas-Specific mAb”,Intl. Immunol., 6(11) :1799-1806 (1994).
Takahashi et al., “Generalized Lymphoproliferative Disease in Mice, Caused by a Point Mutation in the Fas Ligand”,Cell, 76:969-976 (1994).
Tartaglia et al., “A Novel Domain Within the 55 kd TNF Receptor Signals Cell Death”,Cell, 74:845-853 (1993).
Chinnaiyan et al., “Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95”,Science, 274:990-992 (1996).
Yang and Korsmeyer, “Molecular Thanatopis: A Discourse on the BCL2 Family and Cell Death”,Blood, 88(2) :386-401 (1996).
Nalin, “Apoptosis Research Enters the ICE Age”,Structure, 3:143-145 (1995).
Henkart, “ICE Family Proteases: Mediators of All Apoptotic Cell Death?”,Immunity, 4:195-201 (1996).
Alnemri et al., “Human ICE/CED-3 Protease Nomenclature”,Cell, 87:171 (1996).
Muzio et al., “FLICE, A Novel FADD-Homologous ICE/CED-3-Like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex”,Cell, 85:817-827 (1996).
Duan et al., “ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B”,J. Biol. Chem., 271(28) :16720-16724 (1996).
Fernandes-Alnemri et al., “In vitro Activation of CPP32 and Mch3 by Mch4, a Novel Human Apoptotic Cysteine Protease Containing Two FADD-Like Domains”,Proc. Natl. Acad. Sci. USA, 93:7464-7469 (1996).
Chinnaiyan et al., “FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-Induced Apoptosis”,J. Biol. Chem., 271(9) :4961-4965 (1996).
Duan et al., “ICE-LAP3, a Novel Mammalian Homologue of theCaenorhabditis elegansCell Death Protein Ced-3 Is Activated During Fas- and Tumor Necrosis Factor-Induced Apoptosis”,J. Biol. Chem., 271(3):1621-1625 (1996).
Schlegel et al., “CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis”,J. Biol. Chem., 271 (4) :1841-1844 (1996).
Chapman, K.T., “Synthesis of a Potent Reversible Inhibitor of Interleukin-1β Converting Enzyme”,Bioorg. Med. Chem. Lett., 2:613-618 (1992).
Thornberry et al., “A Novel Heterodimeric Cysteine Protease is Required for Interleukin-1β Processing in Monocytes”,Nature, 356:768-774 (1992).
Thornberry et al., “Inactivation of Interleukin-1β Converting Enzyme by Peptide (Acyloxy) methyl Ketones”,Biochemistry, 33:3934-3940 (1994).
Rotonda et al., “The Three-Dimensional Structure of Apopain/CPP32, a Key Mediator of Apoptosis”,Nature Struct. Biol., 3(7) :619-625 (1996).
Pronk et al., “Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER”,Science, 271:808-810 (1996).
Fearnhead et al., “An Interleukin-1β- Converting Enzyme-like Protease is a Common Mediator of Apoptosis in Thymocytes”,FEBS Lett., 375:283-288 (1995).
Ramarli et al., “Selective Inhibition of Interleukin 2 Gene Function Following Thymocyte Antigen/Major Histocompatibility Complex Receptor Crosslinking: Possible Thymic Selection Mechanism”,Proc. Natl. Acad. Sci. USA, 84:8598-8602 (1987).
Kappler et al., “T Cell Tolerance by Clonal Elimination in the Thymus”,Cell, 49:273-280 (1987).
Vasquez et al., “In Vivo and In Vitro Clonal Deletion of Double-Positive Thymocytes”,J. Exp. Med., 175:1307-1316 (1992).
Ashton-Rickardt et al., “Evidence for a Differential Avidity Model of T Cell Selection in the Thymus”,Cell, 76:651-663 (1994).
Hogquist et al., “T Cell Receptor Antagonist Peptides Induce Positive Selection”,Cell, 76:17-27 (1994).
Sebzda et al. “Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide”,Science 263:1615-1618 (1994).
Williams, “Thyroid Disease: A Case of Cell Suicide?”,Science, 275:926 (1997).
Walker, et al., “Crystal Structure of the Cystein Protease Interleukin-1β-Converting Enzyme: A (p20/p10)2Homodimer”,Cell, 78:343-352 (1994).
Wilson, et al., “ Structure and Mechanism of Interleukin-1β Converting Enzyme”,Nature, 370:270-275 (1994).
Sentman, et al., “bcl-2 Inhibits Multiple Forms of Apoptosis but Not Negative Selection in Thymocytes”,Cell, 67:879-888 (1991).
Li, et al., “Mice Deficient in IL-1β-Converting Enzyme Are Defective in Productin of Mature IL-1β and Resistant to Endotoxic Shock”,Cell, 80:401-411 (1995).
Kuida, et al., “Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme”,Science, 267:2000-2003 (1995).
Rozzo, et al., “Development of the T Cell Receptor Repertoire inlprMice”,Sem. in Immunol., 6:19-26 (1994).
Smith et al., “CrmA Expression in T Lymphocytes of Transgenic Mice Inhibits CD95 (Fas/APO-1)-Transduced Apoptosis, but Does Not Cause Lymphadenopathy or Autoimmune Disease”,EMBO J., 15(19) :5167-5176 (1996).
Crispe, “Fatal Interactions: Fas-Induced Apoptosis of Mature T Cells”,Immunity, 1:347-349 (1994).
Clayton, L.K., et al., “T-cell Receptor Ligation by Peptide/MHC Induces Activation of a Caspase in Immature Thymocytes: The Molecular Basis of Negative Selection,”The EMBO Journal, 16(9): 2282-2293 (1997).
Alam, A., et al., “Specific Activation of the Cysteine Protease CPP32 During the Negative Selection of T Cells in the Thymus,”J. Exp. Med, 186 (9) : 1503-1512 (1997).
Tewari, M., et al., “Yama/CPP32β, a Mammalian Homolog of CED-3, Is a CrmA-Inhibitable Protease That Cleaves the Death Substrate Poly (ADP-Ribose) Polymerase,”Cell, 81: 801-809 (1995).
Fernandes-Alnemri, T., et al., &#x
Clayton Linda
Ocain Timothy D.
Patch Raymond J.
Reinherz Ellis
Dana-Farber Cancer Institute
Hamilton Brook Smith & Reynolds P.C.
Yaen Christopher H.
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