Methods of identifying agents that diminish cellular...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C424S093510, C435S254210, C435S255100, C435S255200, C435S029000

Reexamination Certificate

active

07452670

ABSTRACT:
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.

REFERENCES:
patent: WO 02/065136 (2002-08-01), None
Moore et al. Annu. Rev. Neurosci. 2005. 28: 57-87.
Ambrose et al., “Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat,”Somat. Cell Mol. Genet. 20:27-38 (1994).
Clayton and George, “Synucleins in synaptic plasticity and neurodegenerative disorders,”J. Neurosci. Res.58:120-129 (1999).
Cummings et al., “Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function inSCAImice,”Hum. Mol. Genet.10:1511-1518 (2001).
Engelender et al., “Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions, ”Nat. Genet.22:110-114 (1999).
Fernandez-Funez et al., “Identification of genes that modify ataxin-1-induced neurodegeneration,”Nature408:101-106 (2000).
George et al., “Characterization of a novel protein regulated during the critical period for song learning in the zebra finch,”Neuron15:361-372 (1995).
Goedert, “Alpha-synuclein and neurodegenerative diseases,”Nat. Rev. Neurosci.2:492-501 (2001).
Grunenfelder and Winzeler, “Treasures and traps in genome-wide data sets: case examples from yeast,”Nat. Rev. Genet.3:653-61 (2002).
Gusella and MacDonald, “Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease,”Nat. Rev. Neurosci. 1:109-115 (2000).
Hardy and Selkoe, “The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics,”Science297:353-356 (2002).
Huntington's Disease Collaborative Research Group, “A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes,”Cell72:971-983 (1993).
Kazemi-Esfarjani and Benzer, “Genetic suppression of polyglutamine toxicity inDrosophila,”Science287:1837-1840 (2000).
Kruger et al., “Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease,”Nat. Genet.18:106-08 (1998).
Lotharius and Brundin, “Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein,”Nat. Rev. Neurosci. 3:932-942 (2002).
Muchowski et al., “Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloids-like fibrils,”Proc. Natl. Acad. Sci. USA97:7841-7846 (2000).
Polymeropoulos et al., “Mutation in the α-synuclein gene identified in families with Parkinson's Disease,”Science276:2045-2047 (1997).
Rochet and Lansbury Jr., “Amyloid Fibrillogenesis: themes and variations,”Curr. Opin. Struct. Biol.10:60-88 (2000).
Scherzinger et al., “Huntington-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo,”Cell90:549-558 (1997).
Volles et al., “Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson'disease,”Biochemistry40:7812-7819 (2001).
Warrick et al., “Suppression of polyglutamine-mediated neurodegeneration inDrosophilaby the molecular chaperone HSP70,”Nat. Genet.23:425-428 (1999).
Zoghbi and Orr, “Glutamine repeats and neurodegeneration,”Ann. Rev. Neurosci.23:217-247 (2000).

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