Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-09-20
2005-09-20
Li, Ruixiang (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007100, C435S007200, C435S007210, C435S007900, C435S006120
Reexamination Certificate
active
06946244
ABSTRACT:
The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
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patent: 6358695 (2002-03-01), Sathe et al.
patent: 2003/0059878 (2003-03-01), Onuki et al.
patent: WO-200053742 (2000-09-01), None
A-Geneseq, Accession No. AAB74397, Feb. 27, 2001.
A-Geneseq, Accession No. AAB74494, 2001.
Wittenberger, et al.An Expressed Sequence Tag(EST)Data Mining Strategy Succeeding in the Discovery of New G-Protein Coupled Receptors. (2001), J. Mol. Biol. 307:799-813.
Boeynaems Jean-Marie
Brezillion Stephane
Communi Didier
Detheux Michel
Lannoy Vincent
Euroscreen S.A.
Li Ruixiang
Palmer & Dodge LLP
Williams Kathleen M.
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