Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1997-01-31
1999-03-02
Bawa, Raj
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 46, 514851, A61K 912
Patent
active
058767002
ABSTRACT:
Methods of hydrating lung mucous secretions in the lungs of a subject are disclosed. The methods involve administering benzamil or phenamil to the lungs of the subject in an amount effective to hydrate lung mucous secretions. The administering step is preferably carried out by inhalation administration. The method is useful in the treatment of diseases such as cystic fibrosis and chronic bronchitis.
REFERENCES:
patent: 3313813 (1967-04-01), Cragoe, Jr. et al.
patent: 4501729 (1985-02-01), Boucher et al.
patent: 5292498 (1994-03-01), Boucher, Jr.
patent: 5304125 (1994-04-01), Leith
patent: 5512269 (1996-04-01), Uedia et al.
patent: 5635160 (1997-06-01), Stutts, III et al.
patent: 5656256 (1997-08-01), Boucher et al.
M. R. Knowles, et al; Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis, N Engl J Med 325, pp. 533-538 (1991).
S.J. Mason et al; Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium, Br. J. Pharmacol. 103, pp. 1649-1656 (1991).
N.J. Willumsen and R.C. Boucher; Sodium transport and intracellular sodium activity in cultured human nasal epithelium, Am. J. Physiol. (Cell Physiol 25) 256 C1033-C1053 (1989).
Boucher, Jr. Richard C.
Stutts Monroe Jackson
Bawa Raj
The University of North Carolina at Chapel Hill
LandOfFree
Methods of hydrating lung mucous secretions with benzamil or phe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of hydrating lung mucous secretions with benzamil or phe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of hydrating lung mucous secretions with benzamil or phe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-419591