Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-11-06
2007-11-06
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S455000, C435S456000, C435S091400, C435S091410, C435S091420, C435S235100, C435S239000
Reexamination Certificate
active
10465302
ABSTRACT:
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding termini from an adenovirus which grow efficiently in the desired cell line. At a minimum, the left terminus spans the 5′ inverted terminal repeat, the left terminus spans the E4 region and the 3′ inverted terminal repeat. The resulting chimeric adenovirus contains the internal regions spanning the genes encoding the penton, hexon and fiber from the serotype which does not grow efficiently in the desired cell. Also provided are vectors constructed from novel simian adenovirus sequences and proteins, host cells containing same, and uses thereof.
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STIC Sequence/Fragment search results 14, 15, .rag.
Roy Soumitra
Wilson James M.
Guzo David
Howson & Howson LLP
The Trustees of the University of Pennsylvania
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