Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2005-10-28
2011-11-08
Juedes, Amy (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S002000
Reexamination Certificate
active
08053235
ABSTRACT:
The present invention provides methods for generating mammalian T cell populations comprising antigen-specific CD4+CD25+ regulatory T cells from freshly isolated CD4+CD25− T cells. The method comprises selecting CD4+CD25− T cells from a sample obtained from a mammalian subject; determining the MHC Class II type of the subject; inducing the generation of antigen-specific regulatory T cells by contacting the isolated CD4+CD25− T cells in a culture vessel with an induction agent for a time period sufficient to generate antigen-specific CD4+CD25+ regulatory T cells; and selecting the CD4+CD25+ antigen-specific regulatory T cells by sorting the cells in the induction culture with a selection agent comprising at least one artificial multimeric MHC Class II/peptide complex that corresponds to the MHC Class II type of the subject.
REFERENCES:
patent: 6316257 (2001-11-01), Flyer et al.
patent: 6576428 (2003-06-01), Assenmacher et al.
patent: 6667175 (2003-12-01), Suciu-Foca
patent: 6759239 (2004-07-01), Suciu-Foca et al.
patent: 2003/0073102 (2003-04-01), Kwok et al.
patent: 2003/0157057 (2003-08-01), Horwitz
patent: 2004/0175373 (2004-09-01), Berenson et al.
patent: 2004/0185034 (2004-09-01), Horwitz
patent: 2004/0191235 (2004-09-01), Groux et al.
patent: 2005/0186207 (2005-08-01), Bluestone et al.
patent: 2005/0196386 (2005-09-01), Blazar et al.
patent: WO 03/059264 (2003-07-01), None
patent: WO 2004/060145 (2004-07-01), None
Horwitz et al., 2004, Seminars in Immunology, vol. 16: 135-143.
Von Herrath et al., 2003, Nat. Reviews, vol. 3: 223-232.
Fantini et al., May 2004, J. Immunol. vol. 172: 5149-5153.
Chen, C., et al., “Induction of Autoantigen-Specific Th2 and Tr1 Regulatory T Cells and Modulation of Autoimmune Diabetes,” Journal of Immunology 171:733-744, 2003.
Chen, W., et al., “Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3,” Journal of Experimental Medicine 198(12):1875-1886, 2003.
Zheng, S.G., et al., “Generation Ex Vivo of TGF-β-Producing Regulatory T Cells From CD4+CD25− Precursors,” Journal of Immunology 169:4183-4189, 2002.
Baecher-Allan, C., et al., “CD4+CD25highRegulatory Cells in Human Peripheral Blood,”Journal of Immunology167:1245-1253, 2001.
Bill, J.R., and B.L. Kotzin, “Use of Soluble MHC Class II/Peptide Multimers to Detect Antigen-Specific T Cells in Human Disease,”Arthritis Research4(4):261-265, 2002.
Bluestone, J.A., and Q. Tang, “Therapeutic Vaccination Using CD4+CD25+Antigen-Specific Regulatory T Cells,”PNAS Early Edition, 2004.
Buckner, J.H., et al., “Defining Antigen-Specific Responses With Human MHC Class II Tetramers,”J. Allergy Clin. Immunol. 110(2): 199-208, Aug. 2002.
Cao, D., et al., “CD25brightCD4+Regulatory T Cells Are Enriched in Inflamed Joints of Patients With Chronic Rheumatic Disease,”Arthritis Research&Therapy6(4):R335-R346, Jun. 7, 2004.
Cleland, L.G., and G. Mayrhofer, “Mucosal Tolerance and Rheumatoid Arthritis,”British Journal of Rheumatology36(11):1139-1143, 1997.
Ettinger, R.A., and G.T. Nepom, “Molecular Aspects of HLA Class II αβ Heterodimers Associated With IDDM Susceptibility and Protection,”Rev. Immunogenetics2:88-94, 2000.
Joffre, O., et al., “Induction of Antigen-Specific Tolerance to Bone Marrow Allografts With CD4+CD25+T Lymphocytes,”Blood103(11):4216-4221, Jun. 1, 2004.
Mallet-Designe, V.I., et al., “Detection of Low-Avidity CD4+T Cells Using Recombinant Artificial APC: Following the Antiovalbumin Immune Response,”J. Immunol. 170:123-131, 2003.
Nakamura, K., et al., “Cell Contact-Dependent Immunosuppression by CD4+CD25+Regulatory T Cells is Mediated by Cell Surface-Bound Transforming Growth Factor β,”Journal of Experimental Medicine194(5):629-644, Sep. 3, 2001.
Nepom, G.T., et al., “HLA Class II Tetramers: Tools for Direct Analysis of Antigen-Specific CD4+T Cells,”Arthritis&Rheumatism46(1):5-12, Jan. 2002.
Nepom, G.T., et al., “MHC Peptide Tetramer Core,”Immune Tolerance Network, 2002-2003, <http://www.immunetolerance.org/research/core/facilities/mhcpeptide.html> [retrieved Oct. 6, 2004].
Novak, E.J., et al., “MHC Class II Tetramers Identify Peptide-Specific Human CD4+T Cells Proliferating in Response to Influenza A Antigen,”Journal of Clinical Investigation104:R63-R67, 1999.
Reijonen, H., et al., “Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects,”Diabetes51:1375-1382, May 2002.
Sakaguchi, S., et al., “Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains (CD25),”Journal of Immunology155:1151-1164, 1995.
Schubert, L.A., et al., “Scurfin (FOXP3) Acts As a repressor of Transcription and Regulates T Cell Activation,”Journal of Biological Chemistry276(40):37672-37679, Oct. 5, 2001.
Taams, L.S., et al., “Antigen-Specific T Cell Suppression by Human CD4+CD25+Regulatory T Cells,”Eur. J. Immunol. 32:1621-1630, 2002.
Takahashi, K., et al., “Origins and Divergence Times of Mammalian Classs II MHC Gene Clusters,”Journal of Heredity91(3):198-204, 2000.
Tang, Q., et al., “In Vitro-Expanded Antigen-Specific Regulatory T Cells Suppress Autoimmune Diabetes,”J. Exp. Med. 199(11):1455-1465, Jun. 7, 2004.
Vigouroux, S., et al., “Antigen-Induced Regulatory T Cells,”Blood104(1):26-33, Jul. 1, 2004.
Walker, M.R., et al., “De NovoGeneration of Antigen-Specific CD4+CD25+Regulatory T Cells from Human CD4+CD25−Cells,”PNAS102(11):4103-4108, Mar. 15, 2005.
Walker, M.R., et al., “Induction of Antigen-Specific CD4+CD25+Regulatory T Cells from Human CD4+CD−Cells,” Benaroya Research Institute, presented at the Focus Meeting, Seattle, Washington, Jul. 2004.
Walker, M.R., et al., “Induction of FoxP3 and Acquisition of T Regulatory Activity by Stimulated Human CD4+CD25−T Cells,” Benaroya Research Institute, presented at the Keystone Meeting, Seattle, Washington, Feb. 2004.
Walker, M.R., et al., “Induction of FoxP3 and Acquisition of T Regulatory Activity by Stimulated Human CD4+CD−T Cells,”Journal of Clinical Investigation112(9):1437-1443, Nov. 2003.
Wang, H.Y, et al., “Tumor-Specific Human CD4+Regulatory T Cells and Their Ligands: Implications for Immunotherapy,”Immunity20:107-118, Jan. 2004.
Mallone, R., and G.T. Nepom, “MHC Class II Tetramers and the Pursuit of Antigen-Specific T Cells: Define, Deviate, Delete,” Clinical Immunology 110(3):232-242, Mar. 2004.
Walker, M.R., et al., “Induction of FoxP3 and Acquisition of T Regulatory Activity by Stimulated Human CD4+CD25− T Cells,” The Journal of Clinical Investigation 112(9):1437-1443, Nov. 2003.
Walker, M.R., et al., “De Novo Generation of Antigen-Specific CD4+CD25+ Regulatory T Cells From Human CD4+CD25− Cells,” PNAS 102(11):4103-4108, Mar. 15, 2005.
Danke, N. A., et al., “Autoreactive T Cells in Healthy Individuals,” Journal of Immunology 172(10):5967-5972, May 2004.
Danke, N. A., et al., “Comparative Study of GAD65-Specific CD4+ T Cells in Healthy and Type 1 Diabetic Subjects,” Journal of Autoimmunity 25(4):303-311, Dec. 2005.
Sakaguchi, S., “The Origin of FOXP3-Expressing CD4+ Regulatory T Cells: Thymus or Periphery,” Journal of Clinical Investigation 112(9):1310-1312, Nov. 2003.
Tarbell, K.V., et al., “CD25+ CD4+ T Cells, Expanded With Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes,” Journal of Experimental Medicine 199(11):1467-1477, Jun. 2004.
European Examination Report dated Nov. 26, 2009, issued in corresponding European Application No. 058
Buckner Jane H.
Walker Mindi R.
Benaroya Research Institute at Virginia Mason
Christensen O'Connor Johnson & Kindness PLLC
Juedes Amy
LandOfFree
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