Methods of electrochemical assay employing a field effect transi

Details Methods of electrochemical assay employing a field effect transi Methods of electrochemical assay employing a field effect transi

1985-03-15

1988-10-18

Warden, Robert J.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

204403, 204416, 357 25, 435176, 435817, 436517, 436524, 436525, 436527, 436806, 436807, G01N 33551, G01N 33552, G01N 33553, G01N 33557

Patent

active

047787694

ABSTRACT:
In its broadest aspect, the present invention provides a method of assaying a ligand in a sample which comprises contacting the sample with a predetermined quantity of a specific binding partner to the ligand, said specific binding partner being immobilized on the effective gate electrode of a field effect transistor, and determining whether (and, if desired, the extent to which) an appropriate transistor characteristic is changed as a result of complex formation between the ligand and the specific binding partner.

REFERENCES:
patent: 4020830 (1977-05-01), Johnson et al.
patent: 4238757 (1980-12-01), Schenck
patent: 4273636 (1981-06-01), Shimada et al.
patent: 4411741 (1983-10-01), Janata
patent: 4437969 (1984-03-01), Covington et al.
Naoto Yamamoto, et al., "Antigen-Antibody Reaction Investigated with Use of a Chemically Modified Electrode", Clinical Chemistry, vol. 26, No. 11, 1980, pp. 1569-1572.

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