Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-15
2008-04-15
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100
Reexamination Certificate
active
10945772
ABSTRACT:
Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
REFERENCES:
patent: 4752583 (1988-06-01), Jensen
patent: 5538886 (1996-07-01), Schlessinger
patent: 5646333 (1997-07-01), Dobres
patent: 5736149 (1998-04-01), Avjioglu
patent: 5837505 (1998-11-01), Della-Cioppa
patent: 5888794 (1999-03-01), Schlessinger
patent: 5916561 (1999-06-01), Adolf
patent: 1 097 944 (2001-05-01), None
Brennan et al., J. Autoimmunity, 1989, 2 (suppl.): 177-186.
Zimmer, Cell Motility and the Cytoskeleton, 1991. 20:325-337.
Hell et al., Laboratory Investigation, 1995, 73: 492-496.
Fu et al., EMBO J., 1996, 15:4392-4401.
Vallejo et al., Biochimie, 2000 82:1129-1133.
Jang et al., Clinical Exp. Metastasis, 1997, 15: 469-483.
U.S. Appl. No. 09/743,492, Yamamoto et al.
Ahmad et al. “Functional Association Between the Insulin Receptor and the Transmembrane Protein-Tyrosine Phosphatase LAR in Intact Cells.”J Biol Chem., 272:448-57 (1997).
Ahmad et al. “Increased Abundance of the Receptor-Type Protein-Tyrosine Phosphatase LAR Accounts for the Elevated Insulin Receptor Dephosphorylating Activity in Adipose Tissue of Obese Human Subjects”J Clin Invest., 95:2806-12 (1995).
Bendayan, M., “Possibilities of False Immunocytochemical Results Generated by The Use of Monoclonal Antibodies: The Example of the Anti-proinsulin Antibody,”J. Histochem. Cytochem., 43:881-86 (1995).
Besco et al., “Genomic Organization and Alternative Splicing of the Human and Mouse RPTPp Genes,”BMC Genomics, 2:1-13 (2001).
Bost et al., “Antibodies against a peptide sequence within the HIV envelope protein crossreacts with human interleukin-2,” Immunol. Invest., 17(6-7):577-86 (1988).
Debant, et al., “The Multidomain Protein Trio Binds the LAR transmembrane Tyrosine Phosphatase, Contains a Protein Kinase Domain, and has Separate rac-specific and rho-specific Guanine Nucleotide Exchange Factor Domains,”Proc. Natl. Acad. Sci. U.S.A., 93:5466-71 (1996).
Faure et al., “Diagnostic Features of Primary Malignant Lymphomas of the Thyroid with Monoclonal Antibodies,”Cancer(Phila), 61:1852-1861 (1988).
Fernando et al., “Antibodies to the Human 2 Subunit of the GABAa/Benzodiazepine Receptors,”J. Neurochem., 64:1305-1311 (1995).
Furukawa et al. “Specific Interaction of the CD45 Protein-Tyrosine Phosphatase with Tyrosine-Phosphorylated CD3 zeta Chain”Proc Natl Acad Sci U S A., 91:10928-32 (1994).
Goldstein et al., “Regulation of Insulin Receptor Signaling by Protein-Tyrosine Dephosphorylation”,Receptor, 3:1-15(1993).
Hersh, et al., “The Salmonella Invasin SipB Induces Macrophage Apoptosis by Binding to caspase-1,”Proc. Natl. Acad. Sci. U.S.A., 96:2396-401 (1999).
Itoh et al., “Purification and Characterization of the Catalytic Domains of the Human Receptor-linked Protein Tyrosine Phosphatases HPTPβ, Leukocyte Common Antigen (LCA), and Leukocyte Common Antigen-related Molecule (LAR),”J. Biol. Chem., 267:12356-12363 (1992).
Kanemitsu, O., “Koutai Kougaku Nyuumon,” K.K. Chijin Shokan, 145-166 (1994).
Streuli et al. “A New Member of the Immunoglobulin Superfamily that has a Cytoplasmic Region Homologous to the Leukocyte Common Antigen”J Exp Med., 168:1523-30 (1988).
Streuli et al. “Distinct Functional Roles of the Two Intracellular Phosphatase Like Domains of the Receptor-linked Protein Tyrosine Phosphatases LCA and LAR,”EMBO J., 9:2399-407 (1990).
Streuli et al. “Expression of the Receptor-Linked Protein Tyrosine Phosphatase LAR: Proteolytic Cleavage and Shedding of the CAM-like Extracellular Region,”EMBO J., 11:897-907 (1992).
Supplemental European Search Report for EP 99 92 3958 dated Feb. 18, 2004.
Takeuchi et al., “Characterization of AE-6 Monoclonal Antibody Recognizing VHCSAGV Sequence in CD45 PTPase Domain,”Tissue Antigens, 42:441 (1993).
Yakura, “CD45 Isoforms and Functional Diversity of T and B Cells,”Med. Immunol., 27:333-339 (1994). (English translation of Table 1 of p. 334).
Yu et al., “The N-terminal and C-terminal Domains of a Receptor Tyrosine Phosphatase are Associated by Non-covalent Linkage,”Oncogene, 7:1051-1057 (1992).
Zhang et al., “LAR Tyrosine Phosphatase Receptor: Alternative Splicing is Preferential to the Nervous System, Coordinated with Cell Growth and Generates Novel Isoforms Containing Extensive CAG Repeats,”J. Cell Biol., 128:415-431 (1995).
Zhang, et al., “Molecular Cloning and Expression of a Unique Receptor-Like Protein-Tyrosine-Phosphatase in the Leukocyte-Common-Antigen-Related Phosphatase Family,” Biochem J., 302:39-47 (1994).
Konishi Noboru
Tsujikawa Kazutake
Uchino Yukiko
Yamamoto Hiroshi
Fuso PHarmaceutical Industries, Ltd.
Halvorson Mark
Marshall & Gerstein & Borun LLP
Yu Misook
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