Methods of diagnosing susceptibility to obesity

Details Methods of diagnosing susceptibility to obesity Methods of diagnosing susceptibility to obesity

2001-09-18

2008-10-28

Johannsen, Diana B (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023200, C536S023500

Reexamination Certificate

active

07442500

ABSTRACT:
A gene expression pattern analysis has identified genes the expression patterns of which are different in adipose cells of individuals who have Type 2 Diabetes Mellitus from the cells of individuals who do not have the disease. This information provides a mechanism for the genetic diagnosis of the disease.

REFERENCES:
Andreelli, F. et al. Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients. Diabetologia 42:358-364 (Mar. 1999).
Choo,H.J., et al., “Mitochondria are impaired in the adipocytes of type 2 diabetic mice,” Diabetologia 48:784-791 (2006).
Ducluzeau, P-H., et al., “Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue,” Diabetes 50:1134-1142 (2001).
Sewter, C., et al., “Human Obesity and Type 2 Diabetes are Associated with Alterations in SREBP1 Isoform Expression That are Reproduced . . . ,” Diabetes 51:1035-1041 (2002).
Shimomura, I., et al., “Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire . . . ,” J. Biol. Chem. 273:35299-35306 (1998)(abstract).
Yang, X., et al., “Evidence of Impaired Adipogenesis in Insulin Resistance,” Biochem Biophys Res Commun 14:317(4):1045-51 (2004)(abstract).
Yki-Jarvinen, H., “Role of insulin resistance in the pathogenesis of NIDDM,” Diabetologia 38:1378-88 (1995)(abstract).
Asmann, Y.W., et al., “Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles . . . ,” Diabetes 55:3309-3319 (2006).
Lee, Y.H., et al., “Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians . . . ,” Diabetologia 48:1776-1783 (2005).
Clee, S.M., et al., “Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus,” Nature Genetics 38:688-693 (2006).
Clee, S.M., et al., “The Genetic Landscape of Type 2 Diabetes in Mice,” Endocrine Reviews 28:48-83 (2007).
Goodarzi, M.O., et al., “SORCS1: A Novel Human Type 2 Diabetes Susceptibility Gene Suggested by the Mouse,” Diabetes 56:1922-1929 (2007).
Lee, Y.H., et al., (2005) Electronic supplementary material is available in the online version of this article at http://dx.doi.org/10.1007/s00125-005-1867-3.
Montague, C.T., et al., “Congenital leptin deficiency is associated with severe early-onset obesity in humans,” Nature 387:903-908 (1997).
Stoehr, J.P., et al., “Genetic Obesity Unmasks Nonlinear Interactions Between Murine Type 2 Diabetes Susceptibility Loci,” Diabetes 49:1946-1954 (2000).
Zhang, Y., “Positional cloning of the mouse obese gene and its human homologue,” Nature 372:425-432 (1994).

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