Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-01-06
1996-10-22
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 721, 436501, 436503, 436504, 514825, 514826, 514886, C07K 1472, G01N 3353, G01N 33567
Patent
active
055675905
ABSTRACT:
Disclosed is a method for diagnosing inflammation in an animal which includes analyzing cells to assess glucocorticoid receptor binding affinity or glucocorticoid receptor number. A low binding affinity and high receptor number are each indicative of inflammation. Also disclosed is a method for treating inflammation in an animal, which inflammation causes glucocorticoid receptor alteration which includes suppressing the activity or expression of cytokines which, in the absence of suppression, alter glucocorticoid receptors. Also disclosed are methods for identifying Type II glucocorticoid receptor binding abnormality and for distinguishing Type I glucocorticoid receptor binding abnormalities from Type II. Further disclosed are treatments for steroid-resistant inflammatory disorders induced by IL-2 and IL-4 which are associated with glucocorticoid receptor binding abnormalities. The treatment includes administering an agent which is an IL-2 suppressor and/or an IL-4 suppressor.
REFERENCES:
Peterson et al. 1981. J. Allergy Clin. Immunol. 68: 212-217.
Sher et al. 1992. J. Allergy Clin. Immunol. 89:285.
Muller et al. 1991. Biochim. et Biophys. Acta 1088: 171-182.
Kam et al., "Combination IL-2 and IL-4 Reduces Glucocorticoid Receptor-Binding Affinity and T Cell Response to Glucocorticoids", pp. 3460-3466, 1993, J. Immunol., vol. 151, Oct.
Leung Donald Y. M.
Spahn Joseph D.
Szefler Stanley J.
Kemmerer Elizabeth C.
National Jewish Center for Immunology and Respiratory
Walsh Stephen G.
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