Methods of diagnosing parasitic infections and of testing drug s

Details Methods of diagnosing parasitic infections and of testing drug s Methods of diagnosing parasitic infections and of testing drug s

1994-03-25

1996-10-15

Gitomer, Ralph J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 24, 435 34, 436811, C12Q 142, C12Q 104

Patent

active

055653278

ABSTRACT:
The CTD kinase of sporozoan parasites displays a specificity distinct from the analogous activity in mammalian cells. Methods of diagnosing blood borne Plasmodium parasites, and of testing the susceptibility of Plasmodium parasites to anti-malarial drugs, are based on this specificity.

REFERENCES:
patent: 5061788 (1991-10-01), Certa
patent: 5112749 (1992-05-01), Brey
Knighton et al., Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase, Science, 253:414-420 (1991).
Lee et al., CTD kinase large subunit is encoded by CTKI, a gene required for normal growth of Saccharomyces cerevisiae, Gene Expression, 1:149-167 (1991).
Giesecke et al., The C-Terminal Domain of RNA Polymerase II of the Malaria Parasi, Biochemical and Biophysical Research Communications, 180:1350-1355 (1991).
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Allison et al., The C-Terminal Domain of the Largest Subunit of RNA Polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and Mammals: a Conserved Structure with an Essential Function, Molecular and Cellular Biology, 8:321-329 (1988).
Weeks et al., Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript process, Genes & Development, 7:2329-2344 (1993).
Lee et al., A protein kinase phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II, Biochemistry, 86:3624-3628 (1989).
Drug Resistance in Malaria, WHO Technical Report Series, No. 529, pp. 102-118 (1973).
Lee, JM., CTD Kinase Large Subunit is Encoded . . . Gene Expression vol. 1 #2, May 1991 pp. 149-167.
Giesecre H., The C-Terminal Domain of RNA . . . Biochem Biophys Res Com vol. 180 #3, 1991 pp. 1350-1355.

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