Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-14
2005-06-14
Myers, Carla J. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023500, C536S024310, C536S024330
Reexamination Certificate
active
06905822
ABSTRACT:
The invention relates to the discovery that a putative gene ofMycobacterium tuberculosiswith no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. SinceM. tuberculosishas a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed “EtaA,” are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.
REFERENCES:
Ahern et al. The Scientist, 1995 vol. 9 #15, p. 20.
Badcock et al, Jan. 14, 1997, Sanger centre Wellcome Genome campus.
Phillip et al., PNAS vol. 93, pp 3132-3137, Apr. 1996.
DeBarber et al. , PNAS vol. 97, No. 17, pp 9677-9682.
Boehringer Mannheim 1997 Biochemicals Catalog p. 95.
Barry, III Clifton E.
Bekker Linda-Gail
DeBarber Andrea E.
Mdluli Khisimuzi
Myers Carla J.
Sakelaris Sally
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
LandOfFree
Methods of diagnosing multidrug resistant tuberculosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of diagnosing multidrug resistant tuberculosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of diagnosing multidrug resistant tuberculosis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3498972