Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-06
1998-12-01
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 721, 436 63, 436 64, G01N 33574, G01N 3353, G01N 33567, G01N 3348
Patent
active
058436863
ABSTRACT:
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.
REFERENCES:
Harlow & Lane (1988) Antibodies, A Laboratory Manual. Cold Spring Harbor Lab. Chapters 6 & 14.
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Lukanidin Eugene
Zain Sayeeda
Eyler Yvonne
Feisee Lila
Research Corporation Technologies Inc.
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