Methods of diagnosing and monitoring rheumatic diseases

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 792, 435 794, 435 795, 436506, 436509, 436518, 436804, 436811, G01N 33573, G01N 33564

Patent

active

053407202

ABSTRACT:
Assays which aid in diagnosing systemic lupus erythematosus and rheumatoid arthritis are disclosed. One assay tests urine samples for the presence or absence of an RNA polymerase I antibody which specifically binds with RNA polymerase I antigen and another assay tests for the presence or absence of an RNA polymerase I antigen that specifically binds with an antibody to RNA polymerase I.

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Stetler and Cavallo, "Anti-RNA Polymerase Antibodies: Potential Role in the Induction and Progression of Murine Lupus Nephritis", J. Immunol. 138(7) pp. 2119-2123 (Apr. 1, 1987).
Coonrod, "Urine as an Antigen Reservoir for Diagnosis of Infectious Diseases." The American Journal of Medicine pp. 85-92 (Jul. 28, 1983).

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