Methods of diagnosing a predisposition for osteoarthritis via de

Details Methods of diagnosing a predisposition for osteoarthritis via de Methods of diagnosing a predisposition for osteoarthritis via de

1997-04-21

1999-08-17

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, C12Q 168, C12P 1934

Patent

active

059392606

ABSTRACT:
A method of diagnosing a disease associated with a genetic polymorphism in a vitamin D receptor gene comprises determining the genotype of said vitamin D receptor gene in an animal. The method can be used to diagnose predisposition or susceptibility to osteoarthritis. Compositions for said diagnosis are provided. Methods of treatment of osteoarthritis are provided, comprising identifying an individual having a predisposition or susceptibility to the disease and subsequently treating that individual.

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Uitterlinden et al., J. Bone Mineral. Res. 11(9), 1241-1248. (only abstract provided), 1996.
Uitterlinden et al., Bone 20(4 Suppl.), 10S (abstract), 1997.
Brandt, K.D., and Kovalov-St. John, K., "Osteoarthritis," Chapter 281, in: Harrison's Principles of Internal Medicine, Twelfth Edition (International Edition), vol. 2, Wilson, J.D., et al., Eds., McGraw-Hill, Inc.; pp. 1475-1479 (1991).
Griffiths, G.O., et al., "Polymorphisms of the Vitamin D Receptor and Osteoarthritis," British Journal of Rheumatology 35 (Suppl. 1):117 (May 1996).
Morrison, N.A., et al., "Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin," Proc. Natl. Acad. Sci. USA 89:6665-6669 (1992).
Morrison, N.A., et al., "Prediction of bone density from vitamin D receptor alleles," Nature 367:284-287 (1994).
Spector, T.D., et al., "Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain," British Medical Journal 310:1357-1360 (May 1995).

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