Methods of determining initiation and variable end points for me

Details Methods of determining initiation and variable end points for me Methods of determining initiation and variable end points for me

1997-04-15

1999-03-23

Soderquist, Arlen

Chemistry: analytical and immunological testing

Rate of reaction determination

436 46, 436 50, 436 67, 436 87, 436 93, 436 94, 436 95, 436169, G01N 3300

Patent

active

058858393

ABSTRACT:
The present invention provides a method of using a reflectance-reading device to determine an initiation time point for measuring the chemical reaction of an analyte from a biological liquid sample on a test surface. The initiation time point is determined by using a device to read a reflectance of a test surface at a plurality of time points, and calculating the K/S ratio of the test surface at each time point according to the Kubelka-Munk equation. As the device continues to calculate a K/S ratio for each time point, the device monitors the rate of change of the K/S ratio with respect to time. The device then determines the initiation time point to be when the rate of change of the K/S ratio is maximal. The present invention also provides a method of measuring the concentration of an analyte on a test surface. The concentration is measured by determining an initiation time point according to the method described above and then measuring the concentration of the analyte at a variable end point. The variable end point is essentially determined to be the time at which the rate of change of a concentration parameter is less than a threshold value.

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