Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Glycoproteins
Patent
1982-12-15
1987-02-10
Turk, Arnold
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Glycoproteins
436 8, 436 14, 436 15, 436 34, 436 88, 436 95, 436904, G01N 3366, G01N 3368
Patent
active
046422951
ABSTRACT:
The determination of fructosamine levels in at least part of a blood sample for use in detecting diabetes in patients or deciding treatment levels is effected by controlling the temperature and pH of the sample, adding a coloring agent such as a nitro-blue tetrazolium and after a first delay in time taking a first color measurement at a predetermined wavelength and after a second delay in time taking a second color measurement at the predetermined wavelength, then comparing any resultant change between the first and second color measurements with those of standard solutions, the selected timing delays, wavelength, coloring agent and pH conditions being such that any change of color in the coloring agent between the first and second color measurements is caused predominantly by the glucose in the sample that is reacted with an amine group of protein and has undergone a molecular rearrangement to form fructosamine and not materially by any non-specific reducing substance which may be present in the sample.
REFERENCES:
patent: 3682586 (1972-08-01), Ertingshausen et al.
patent: 4200435 (1980-04-01), Stroupe et al.
patent: 4243534 (1981-01-01), Bulbenko
patent: 4268270 (1981-05-01), Gabbay et al.
patent: 4269605 (1981-05-01), Dean et al.
patent: 4371374 (1983-02-01), Cerami et al.
patent: 4399227 (1983-08-01), Niederau et al.
patent: 4407961 (1983-10-01), Sanders
patent: 4409335 (1983-10-01), Hanamoto et al.
Bunn et al, Biochemical and Biophysical Research Communications, vol. 67, No. 1, pp. 103-109, 1975.
Mayer et al, Clin. Chim. Acta, vol. 127, pp. 147-184, 1983.
Goldstein, Clinical Diabetes, vol. 4, No. 1, Cover Article, 1986.
Burrin et al, Ann. Clin. Biochem., vol. 22, pp. 327-342, 1985.
Passey et al, Clin. Chem., vol. 23, No. 1, pp. 131-139, 1977.
Mollering et al, "Principles of Enzymatic Analysis", pp. 136-144, section titled, Visualization of NAD(P)-Dependent Reactions.
Kennedy et al, Annals of Internal Medicine, vol. 95, No. 1, pp. 56-58, 1981.
Johnson et al, Clin. Chim. Acta, vol. 127, pp. 87-95, 1982.
Hodge, "Advances in Carbohydrate Chemistry", vol. 10, Published by Academic Press, Inc., New York, 1955, pp. 169-205.
Koenig et al, N. Engl. J. of Medicine, vol. 295, No. 8, pp. 417-420, Aug. 19, 1976.
Parker et al, Clin. Chem., vol. 27, No. 5, pp. 669-672, 1981.
Josef et al, Chemical Abstracts, vol. 82, Abstract No. 82:70120f.
Trivelli et al, N. Engl. J. of Medicine, vol. 284, No. 7, pp. 353-357, Feb. 18, 1971.
Hill Jr. Robert J.
Turk Arnold
LandOfFree
Methods of determining fructosamine levels in blood samples does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of determining fructosamine levels in blood samples, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of determining fructosamine levels in blood samples will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2362941