Methods of determining chronic hepatitis C infection

Details Methods of determining chronic hepatitis C infection Methods of determining chronic hepatitis C infection

2002-01-18

2008-10-28

Campell, Bruce (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S007100, C530S388300, C530S391100

Reexamination Certificate

active

07442497

ABSTRACT:
Methods for determining chronic hepatitis C infection are provided by the present invention. The methods generally involve determining the optical density of fluid samples which have tested positive for hepatitis C infection using an antibody-based assay. The optical density can then be used to determine in a predictive or probability-based manner whether the fluid sample contains chronic hepatitis C infection or whether the fluid sample merely contains antibodies to hepatitis C infection without resorting to costly molecular detection methods. Thus, the present invention permits differentiation between individuals who have cleared hepatitis C infection but still test positive in an antibody-based assay from individuals having chronic hepatitis C infection.

REFERENCES:
patent: WO 00/26673 (2000-05-01), None
Payan et al., Analyse quantitative des anticorps dirigés contre le virus de l'hépatite C (VHC): application au diagnostic d'infectio chronique par le VHC. Annales de Biologie Clinique 61(3):311-317, 2003.
Teo et al (1992) J Clin Pathol;45:917-920.
Lazizi et al (1992) J Clin Microbiology; 30,4:931-934.
Brillanti et al (1993) Arch Virol (Suppl) 8: 213-218.
Fabrizi et al (1996) Nephrol Dial Transplant. 11: 314-318.
Fong et al (1996) Journal of Medical Virology. 49: 253-258.
Cobas Amplicor Hepatitis C Virus Test, Version 2.0, 1/30-30/30; May 1999.

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