Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-02-07
1996-12-03
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 935 77, 935 78, C12P 1934, C12Q 168
Patent
active
055807224
ABSTRACT:
The invention provided for a method of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease such as atherosclerosis, restenosis or hypertension.
Further provided is a method of determining whether a molecule not previously known to be a modulator of protein biosynthesis is capable of directly and specifically transcriptionally modulating the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease.
Lastly, the invention provides a method of directly and specifically transcriptionally modulating in a human being the expression of a gene encoding a protein of interest associated with treatment of one or more symptoms of a cardiovascular disease, thus ameliorating the disease.
REFERENCES:
patent: 4535058 (1985-08-01), Weinberg et al.
patent: 4601978 (1986-07-01), Karin
patent: 4699877 (1987-10-01), Cline et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 4740461 (1988-04-01), Kaufman
patent: 4740463 (1988-05-01), Weinberg et al.
patent: 4761367 (1988-08-01), Edgell et al.
patent: 4761371 (1988-08-01), Bell et al.
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4827079 (1989-05-01), Evans et al.
patent: 4861709 (1989-08-01), Ulitzer et al.
patent: 4885238 (1989-12-01), Reddel et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 4981783 (1991-01-01), Augenlicht
patent: 4981790 (1991-01-01), Haseltine et al.
patent: 5070012 (1991-12-01), Nolan et al.
patent: 5071773 (1991-12-01), Evans et al.
patent: 5075229 (1991-12-01), Hanson et al.
patent: 5262300 (1993-11-01), Evans et al.
Giguere et al., "Identification of a receptor for the morphogen retinoic acid", Nature 330:624-629 (17 Dec. 1987).
Neuhold et al., "Deoxin-inducible enhancer region upstream from the mouse P-1450 gene and interaction with a heterologous SV-40 promoter", DNA 5 (5):403-412 (1986) abstract.
Vellenga, E. et al., (1988) "Independent Regulation of M-CSF and G-CSF Gene Expression in Human Monocytes," Blood 71 (6):1529-1532.
Lee, M-T. et al., (1990) "Differential Expression of M-CSF, G-CSF, and GM-CSF by Human Monocytes" Biol. Abstr. 89(10)-A5-100645.
Tamura, R. and Cox, G. S., (1988) "Effect of Pyrimidine Deoxynucleosides and Sodium Butyrate on Expression of the Glycoprotein Hormone .alpha.-Subunit and Placental Alkaline Phosphatase in HeLa Cells," Chemical Abstracts 108(15):AB-124167.
Andersen, R. et al. (1990) "Metal-Dependent Binding of A Nuclear Factor to the Rat Metallothionein-I Promoter," Nucleic Acids Research 18(20):6049-6055.
Angel, P. et al., (1987 A) "Phorbol Ester-Inducible Genes Contain A Common Cis Element Recognized by An TPA-Modulated Trans-Acting Factor," Cell 49:729-739.
Angel, P. et al., (1987 B) "12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated by an Inducible Enhancer Element Located in the 5'-Flanking Region," Molecular and Cellular Biology, 7:2256-2266.
Bickel, M. et al., (1988) "Granulocyte-Macrophage Colony-Stimulating Factor Regulation in Murine T Cells and Its Relation to Cyclosporin A," Ex. Hematol. 16:691-695.
Blumberg, P., (1988) "Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters: Sixth Rhoads Memorial Award Lecture," Cancer Research 48: 1-8.
Brasier, A. et al., (1989) "Optimized Use of the Firefly Luciferase Assay as a Reporter Gene in Mammalian Cell Lines," BioTechniques 7(10):1116-1122.
Brenner C. et al., (1989) "Message Amplification Phenotyping (MAPPing): A Technique to Simultaneously Measure Multiple mRNAs from Small Numbers of Cells," BioTechniques 7(10): 1096-1103.
Cao, T., (1989) "A Simple and Inexpensive System to Amplify DNA by PCR," BioTechniques 7(6): 566-567.
Cohen, P. and Foulkes, J. G. eds., (1991) The Hormonal Control of Gene Transcription, 92-93, 235-236.
Comb, M. et al. (1986) "A Cyclic AMP- and Phorbol Ester-Inducible DNA Element," Nature 323: 353-356.
Connelly, C. et al., (1989) "The Role of Transgenic Animals in the Analysis of Various Biological Aspects of Normal and Pathologic States," Experimental Cell Research 183: 257-276.
Cybulsky, M. et al., (1991) "Gene Structure, Chromosomal Location, and Basis for Alternative mRNA Splicing of the Human VCAM1 Gene," Proc. Natl. Acad. Sci. USA 88:7859-7863.
Das, H. et al., (1988) "Cell Type-Specific Expression of the Human ApoB Gene Is Controlled by Two Cis-Acting Regulatory Regions," Journal of Biological Chemistry 263 (23): 11452-11458.
de Wet et al., (1987) "Firefly Luciferase Gene: Structure and Expression in Mammalian Cells," Molecular and Cellular Biology 7 (2): 725-737.
Emmel, E. et al., (1989) "Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation," Science 246: 1617-1620.
Engebrecht, J. et al., (1985) "Measuring Gene Expression with Light," Science 227: 1345-1347.
Gunter, K. et al., (1989) "Cyclosporin A-Mediated Inhibition of Mitogen-Induced Gene Transcription Is Specific for the Mitogenic Stimulus and Cell Type," Journal of Immunology 142: 3286-3291.
Higuchi, K. et al., (1988) "Tissue-Specific Expression of Apolipoprotein A-I (ApoA-I) Is Regulated by the 5'-Flanking Region of the Human ApoA-I Gene," Journal of Biological Chemistry 263(34): 18530-18536.
Holbrook, N. et al., (1984) "T-Cell Growth Factor: Complete Nucleotide Sequence and Organization of the Gene in Normal and Malignant Cells," Proc. Natl. Acad. Sci. USA 81:1634-1638.
Hsu, M. et al., (1991) "Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat Antagonist," Science, 254: 1799-1802.
Ishii, S. et al., (1985) "Characterization and Sequence of the Promoter Region of the Human Epidermal Growth Factor Receptor Gene," Proc. Natl. Acad. Sci. USA 82: 4920-4924.
Kaushansky, K. et al., (1985) "Genomic Cloning, Characterization, Multilinage Growth-Promoting Activity of Human Granulocyte-Macrophage Colony-Stimulating Factor," Proc. Natl. Acad. Sci. USA 83: 3101-3105.
Kawasaki, E. et al., (1985) "Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)," Science 230: 291-296.
Knott, T. et al., (1986) "Complete Protein Sequence and Identification of Structural Domains of Human Apolipoprotein B," Nature 323: 734-738.
Kronke, M. et al., (1984) "Cyclosporin A Inhibits T-Cells Growth Factor Gene Expression at the Level of mRNA Transcription," Proc. Natl. Acad. Sci. USA 81: 5214-5218.
Ladner, M. et al., (1987) "Human CSF-1: Gene Structure and Alternative splicing of mRNA Precursors," The EMBO Journal 6(9): 2693-2698.
Lamb, P. et al., (1986) "Characterization of the Human p53 Gene," Molecular and Cellular Biology 6(5): 1379-1385.
Lefevre, C. et al., (1987) "Tissue-Specific Expression of the Human Growth Hormone Gene Is Conferred in Part by the Binding of a Specific Trans-Acting Factor," The EMBO Journal 6(4): 971-981.
Lim, K. et al., (1989) "A Simple Assay for DNA Transfection by Incubation of the Cells in Culture Dishes with Substrates for Beta-Galactosidase," BioTechniques 7(6): 576-579.
Lin, F. et al., (1985) "Cloning and Expression of the Human Erythropoietin Gene," Proc. Natl. Acad. Sci. USA 82: 7580-7584.
Majesky, M. et al., (1990) "PDGF Ligand and Receptor Gene Expression during Repair of Arterial Injury," Journal of Cell Biology 111: 2149-2158.
Maniatis, T. et al., (1987) "Regulation of Inducible and Tissue-Specific Gene Expression," Science 236: 1237-1245.
Mayo, K. et al., (1982) "Altered Regulation of the Mouse Metallothionein-I Gene Following Gene Amplification or Transfection," (in Gene Amplification) Schimke, R. T. ed., 67-73.
McCall, C. et al., (1989) "Biotherapy: A New Dimension in Cancer Treatment," Bio/Technology 7: 231-240.
Metzler, D., (1977) Biochemistry: The Chemical Reactions of Living Cells, 116-117.
Munjaal, R. et al., (1989) "In Situ Detection of Progesterone Receptor mRNA in the Chicken Oviduct Using Probe-on Slides," BioTechniques 7(10): 1104-1108.
Myoken, Y. et al., (1991) "Vascular Endothelia
Case Casey C.
Foulkes J. Gordon
Liechtfried Franz E.
Pieler Christian
Stephenson John R.
Oncogene Science, Inc.
White John P.
Zitomer Stephanie W.
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