Methods of detection of epstein barr virus induced genes express

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 44, 536 235, 435 5, C12Q 168

Patent

active

057443017

ABSTRACT:
The present invention relates, in general, to Epstein Barr virus induced (EBI) genes. In particular, the present invention relates to DNA segments coding for EBI 1, EBI 2, or EBI 3 polypeptides; EBI 1, EBI 2, or EBI 3 polypeptides; recombinant DNA molecules; cells containing the recombinant DNA molecules; antisense EBI 1, EBI 2, or EBI 3 constructs; antibodies having binding affinity to an EBI 1, EBI 2, or EBI 3 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of the presence of Epstein Barr Virus; a method of detecting Epstein Barr virus in a sample; and kits containing nucleic acid probes or antibodies.

REFERENCES:
Stein et al., Science, 261:1004-1012, Aug. 1993.
Brown, Washington Post, p. A1 and A22, "Gene Therapy Oversold by Researchers, Journalists", Dec. 1995.
Alfieri et al., "Early Events in Epstein-Barr Virus Infection of Human B Lymphocytes," Virology 181:595-608 (1991).
Bayliss et al., "An Immunoprecipitation Blocking Assay for the Analysis of EBV Induced Antigens," J. Virol. Meth. 7:229-239 (1983).
Bayliss et al., "The Regulated Expression of Epstein-Barr Virus. III. Proteins Specified by EBV During the Lytic Cycle," J. gen. Virol. 56:105-118 (1981).
Birkenbach et al., "Epstein-Barr Virus Latent Infection Membrane Protein Increases Vimentin Expression in Human B-Cell Lines," J. Virol. 63(9):4079-4084 (1989).
Calender et al., "Epstein-Barr Virus (EBV) Induces Expression of B-Cell Activation Markers on in Vitro Infection of EBV-Negative B-Lymphoma Cells," PNAS USA 84:8060-8064 (1987).
Ehlin-Hendriksson et al., "Expression of B-Cell-Specific Markers in Different Burkitt Lymphoma Subgroups," Intl. J. Cancer 39:211-218 (1987).
Favrot et al., "EBV-Negative and -Positive Burkitt Cell Lines Variably Express Receptors for B-Cell Activation and Differentiation," Intl. J. Cancer 38:901-906 (1986).
Gregory et al., "Different Epstein-Barr Virus-B Cell Interactions in Phenotypically Distinct Clones of a Burkitt's Lymphoma Cell Line," J. gen. Virol. 71:1481-1495 (1990).
Henderson et al., "Induction of bcl-2 Expression by Epstein-Barr Virus Latent Membrane Protein 1 Protects Infected B Cells from Programmed Cell Death," Cell 65:1107-1115 (1991).
Hummel, M. and Kieff, E., "Mapping of Polypeptides Encoded by the Epstein-Barr Virus Genome in Productive Infection," PNAS USA 79:5698-5702 (1982).
Knutson, J.C., "The Level of c-fgr RNA is Increased by EBNA-2, and Epstein-Barr Virus Gene Required for B-Cell," J. Virol. 64(6):2530-2536 (1990).
Qualtiere, L.F. and Pearson, G.R., "Epstein-Barr Virus-Induced Membrane Antigens: Immunochemical Characterization of Triton X-100 Solubilized Viral Membrane Antigens from EBV-Superinfected Raji Cells," Intl. J. Cancer 23:808-817 (1979).
Rowe et al., "Differences in B Cell Growth Phenotype Reflect Novel Patterns of Epstein-Barr Virus Latent Gene Expression in Burkitt's Lymphoma Cells," EMBO J. 6(9):2743-2751 (1987).
Rowe et al., "Epstein-Barr Virus Status and Tumour Cell Phenotype in Sporadic Burkitt's Lymphoma," Intl. J. Cancer 37:367-373 (1986).
Spira et al., "Cell-Surface Immunoglobulin and Insulin Receptor Expression in an EBV-Negative Lymphoma Cell Line and Its EBV-Converted Sublines," J. Immunol. 126(1):122-126 (1981).
Stratagene Catalog, p. 39 (1988). Human B Cell Activation, is Superinduced by Epstein Barr Virus," J. Immunol. 134(5):3007-3012 (1985).
Wang et al., "Epstein-Barr Virus Latent Membrane Protein (LMP1) and Nuclear Proteins 2 and 3C are Effectors of Phenotypic Changes in B Lymphocytes: EBNA-2 and LMP1 Cooperatively Induce CD23," J. Virol. 64(5):2309-2318 (1990).
Wang et al., "Epstein-Barr Virus Nuclear Antigen 2 Specifically Induces Expression of the B-Cell Activation Antigen CD23," PNAS USA 84:3452-3456 (1987).
Wang et al., "Epstein-Barr Virus Nuclear Antigen 2 Transactivates Latent Membrane Protein LMP1," J. Virol. 64(7):3407-3416 (1990).
Watson et al., in: Molecular Biology of the Gene, 4th Edition, vol. I, Benjamin/Cummings, Publ., Menlo Park, CA, p. 276 (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of detection of epstein barr virus induced genes express does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of detection of epstein barr virus induced genes express, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of detection of epstein barr virus induced genes express will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1530972

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.