Chemistry: analytical and immunological testing – Nitrogen containing
Reexamination Certificate
2007-05-29
2007-05-29
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Nitrogen containing
C436S063000, C436S086000, C436S110000, C436S164000, C436S166000, C435S006120
Reexamination Certificate
active
11147552
ABSTRACT:
Methods and compositions are disclosed for quantifying and/or identifying a nitroderivative compound, or a residue thereof, and are applicable for assessing in vivo nitrative stress and for aiding in diagnosis of mammalian pathologies such as asthma, atherosclerosis, Alzheimer's disease, inflammation, ischemia, Parkinson's disease, and cancer. A preferred method comprises a) providing a sample containing the nitroderivative compound, or residue thereof, in the form of a diazo compound or residue thereof; b) azo-coupling the diazo compound, or residue thereof, to a target compound capable of producing a signal, to yield an azo-coupled compound; c) isolating the nitroderivative compound, or residue thereof, or the azo-coupled compound; d) quantitating and/or detecting the signal, to yield a quantitation and/or detection result; and e) determining from the quantitation and/or detection result the identity and/or concentration of the nitroderivative compound, or residue thereof, in the sample.
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Beda Nataliya
Martin Emil
Murad Ferid
Nedospasov Andrei
Pimenova Tatiana
Board of Regents of the University of Texas System
Conley & Rose, P.C.
Wallenhorst Maureen M.
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