Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1997-02-25
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C12Q 168
Patent
active
056058012
ABSTRACT:
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events. Furthermore provided are therapeutic and diagnostic methods using such polynucleotide sequences and platelet-activating factor acethylhydrolase products.
REFERENCES:
patent: 5019508 (1991-05-01), Johnson et al.
patent: 5279957 (1994-01-01), Gross
Tjoelker et al. Nature vol. 374 : pp. 549-553 (1995).
Adjei et al., "Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers," Pharm. Res., 7(6):565-569 (1990).
Braquet et al., "Effect of Endothelin-1 on Blood Pressure and Bronchopulmonary System of the Guinea Pig," J. Cardio. Pharm., 13 (Supp. 5):S143-S146 (1989).
Brenner, "The Molecular Evolution of Genes and Proteins: A Tale of Two Serines," Nature, 334:528-530 (Aug. 11, 1988).
Capecchi, "Altering the Genome by Homologous Recombination," Science, 244:1288-1292 (Jun. 16, 1989).
Chapus et al., "Minireview on Pancreatic Lipase and Colipase," Biochimie, 70:1223-1224 (1988).
deBoer et al., "The tac Promoter: A Functional Hybrid Derived From the trp and lac Promoters," Proc. Nat'l Acad. Sci., USA, 80:21-25 (Jan. 1983).
Debs et al., "Lung-Specific Delivery of Cytokines Induces Sustained Pulmonary and Systemic Immunomodulation in Rats," J. Immunol., 140(10):3462-3488 (May 15, 1933).
Denizot et al., "PAF-Acether and Acetylhydrolase in Stool of Patients with Crohn's Disease," Digestive Diseases and Sciences, 37(3):432-437 (Mar., 1992).
Furukawa et al., "Platelet-Activating Factor-Induced Ischemic Bowel Necrosis: The Effect of Platelet-Activating Factor Acetylhydrolase," Ped. Res., 34(2):237-241 (1993).
Grino et al., "BN 52021: A Platelet Activating Factor Antagonist for Preventing Post-Transplant Renal Failure," Anna. Int. Med., 121(5):345-347 (Sep. 1, 1994).
Handley and Saunders, "Platelet Activating Factor and Inflammation in Atherogenesis: Targets for Drug Development," Drug. Dev. Res., 7:361-375 (1986).
Hattori et al., "Purification and Characterization of Bovine Brain Platelet-activating Factor Acetylhydrolase," J. Biol. Chem., 268(25):18748-18753 (Sep. 5, 1993).
Hattori et al., "The Catalytic Subunit of Bovine Brain Platelet-activating Factor Acetylhydrolase Is a Novel Type of Serine Esterase," J. Biol. Chem., 269(37):23150-23155 (Sep. 16, 1994).
Henriques et al., "Endothelin-1 Inhibits PAF-induced Paw Oedema and Pleurisy in the Mouse," Br. J. Pharmacol., 106:579-582 (1992).
Heuer, H. O., "Current Status of PAF Antagonists," Clin. Exp. Allergy, 22:980-983 (1992).
Hoffman et al., "Detection of Platelet-activating Factor in Amniotic Fluid of Complicated Pregnancies," Am. J. Obstet. Gynecol., 162(2):525-528 (1990).
Horwitz et al., "DNA Sequencies of the araBAD-araC Controlling Region in Salmonella typhimurium LT2," Gene, 14:309-319 (1981).
Hsieh and Ng, "Increased Plasma Platelet-activating Factor in Children with Acute Asthmatic Attacks and Decreased in vivo and in vitro Production of Platelet-activating Factor After Immunotherapy," J. Allergy Clin. Immunol., 91:650-657 (Feb. 1993).
Hsueh et al., "Platelet-activating Factor, Tumor Necrosis Factor, Hypoxia and Necrotizing Enterocolitis," Acta Paediatr., Suppl. 396:11-17 (1994).
Hubbard et al., "Anti-Neutrophil-Elastase Defenses of the Lower Respiratory Tract in .alpha.1-Antitrypsin Deficiency Directly Augmented with an Aerosol of A1-Antitrypsin," Annals of Internal Medicine, 111(3):206-212 (Aug. 1, 1989).
Kald et al., "Release of Platelet-Activating Factor in Acute Experimental Pancreatitis," Pancreas, 8(4):440-442 (1993).
Kurosawa et al., "Increased Levels of Blood Platelet-activating Factor in Bronchial Asthmatic Patients With Active Symptoms," Allergy, 49:60-63 (1994).
LaVallie et al., "A Thioredoxin Gene Fusion Expression System That Circumvents Inclusion Body Formation in the E. coli Cytoplasm," Bio/Technology, 11:187-193 (Feb. 11, 1993).
Lewin, B., In: Genes V, Oxford University Press, New York, New York, Chapter 6, pp. 136-140 (1994).
Lindsberg et al., "Evidence for Platelet-Activating Factor as a Novel Mediator in Experimental Stroke in Rabbits," Stroke, 21(10):1452-1457 (Oct., 1990).
Lindsberg et al., "Platelet-activating Factor in Stroke and Brain Injury," Ann. Neurol., 30(2):117-129 (Aug., 1991).
Maki et al., "Platelet-activating Factor Acetylhydrolase Activity in Maternal, Fetal, and Newborn Rabbit Plasma During Pregnancy and Lactation," Proc. Nat'l Acad. Sci., USA, 85:728-732 (Feb., 1988).
Matsumoto et al., "Platelet-Activating Factor in Bronchoalveolar Lavage Fluid of Patients With Adult Respiratory Distress Syndrome," Clin. Exp. Pharmacol. Physiol., 19:509-515 (1992).
Matsuzaki et al., "PAF Acetylhydrolase Activities in Human Systemic Lupus Erythematosus and Lupus-prone Mice," Clinica Chimica Acta, 210:139-144 (1992).
Mezzano et al., "Detection of Platelet-Activating Factor in Plasma of Patients with Streptococcal Nephritis," J. Am. Soc. Nephrol., 4:235-242 (1993).
Miwa et al., "Characterization of Serum Platelet-activating Factor (PAF) Acetylhydrolase," J. Clin. Invest., 82:1983-1991 (Dec., 1988).
Rabinovici et al., "ARDS-like Lung Injury Produced by Endotoxin in Platelet-activating Factor-primed Rats," J. Appl. Physiol., 74(4):1791-1802 (1993).
Rabinovici et al., "Platelet Activating Factor Mediates Interleukin-2-induced Lung Injury in the Rat," J. Clin. Invest., 89:1669-1673 (May, 1992).
Rodriguez-Roisin et al., "Platelet-activating Factor Causes Ventilation-Perfusion Mismatch in Humans", J. Clin. Invest., 93:188-194 (Jan., 1994).
Satoh et al., "Platelet-activating Factor (PAF) Stimulates the Production of PAF Acetylhydrolase by the Human Hepatoma Cell Line, HepG2," J. Clin. Invest., 87:476-481 (Feb., 1991).
Satoh et al., "Platelet-Activating Factor Acetylhydrolase in Plasma Lipoproteins From Patients With Ischemic Stroke," Stroke, 23(8):1090-1092 (1992).
Smith et al., "Pulmonary Deposition and Clearance of Aerosolized Alpha-1-Proteinase Inhibitor Administered to Dogs and to Sheep," J. Clin. Invest., 84:1145-1154 (Oct., 1989).
Stafforini et al., "Human Macrophages Secrete Platelet-activating Factor Acetylhydrolase," J. Biol. Chem., 265(17):9682-9687 (Jun. 15, 1990).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhdrolase: Association With Lipoprotein Particles and Role in the Degradation of Platelet-activating Factor," J. Biol. Chem., 262(9):4215-4222 (Mar. 25, 1987).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhydrolase: Purification and Properties," J. Biol. Chem., 262(9):4223-4230 (Mar. 25, 1987).
Stafforini et al., "Platelet-activating Factor Acetylhydrolase Activity in Human Tissues and Blood Cells," LIPIDS, 26(12):979-985 (1991).
Stafforini et al., "The Platelet-activating Factor Acetylhydrolase from Human Erythrocytes: Purification and Properties," J. Biol. Chem., 268(6):3857-3865 (Feb. 25, 1993).
Stafforini et al., "Lipoproteins Alter the Catalytic Behavior of the Platelet-activating Factor Acetylhydrolase in Human Plasma," Proc. Nat'l Acad. Sci., USA, 86:2393-2397 (Apr., 1989).
Stremler et al., "Human Plasma Platelet-activating Factor Acetylhydrolase," J. Biol. Chem., 266(17):11095-11103 (Jun. 15, 1991).
Tarbet et al., "Liver Cells Secrete the Plasma Form of Platelet-activating Factor Acetylhydrolase," J. Biol. Chem., 266(25):16667-16673 (Sep., 1991).
Venable et al., "Platelet-activating Factor: A Phospholipid Autacoid With Diverse Actions," J. Lipid Res., 34:691-701 (1993).
Von Heijne, "A New Method for Predicting Signal Sequence Cleavage Sites," Nuc. Acids Res., 14(11):4683-4690 (1986).
Wada et al., "Codon Usage Tabulated from the GenBank Genetic Sequence Data," Nuc. Acids Res., 19S:1981-1986 (1991).
Watanabe et al., "Pharmacological Analysis of Neutrophil Chemotactic Factor Production by Leucocytes and Roles of PAF in Allergic Inflammation in Rats," Br.
Cousens Lawrence S.
Eberhardt Christine D.
Gray Patrick
Tjoelker Larry W.
Trong Hai L.
ICOS Corporation
Whisenant Ethan
Zitomer Stephanie W.
LandOfFree
Methods of detecting lesions in the platelet-activating factor a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of detecting lesions in the platelet-activating factor a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of detecting lesions in the platelet-activating factor a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973467