Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1997-10-21
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 795, 435 405, 435 4052, 5303879, 5303881, G01N 3353, C07K 1618
Patent
active
056795319
ABSTRACT:
The instant invention provides for monoclomal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
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Graham Paul
Konig Gerhard
Allen Marianne P.
Bayer Corporation
Duffy Patricia A.
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