Methods of detecting antibodies to .alpha.-Fodrin and fragments

Details Methods of detecting antibodies to .alpha.-Fodrin and fragments Methods of detecting antibodies to .alpha.-Fodrin and fragments

1998-05-13

2000-09-19

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

435 78, 435194, 530350, G01N 33536

Patent

active

061210579

ABSTRACT:
Screening of the autoantibodies and autoantigens which are specific to Sjogren's syndrome, particularly primary Sjogren's syndrome, and provision of a prophylactic and therapeutic drug for Sjogren's syndrome, particularly primary Sjogren's syndrome, and a highly sensitive diagnostic agent for Sjogren's syndrome. The .alpha.-fodrin or .alpha.-fodrin fragment of the invention is an antigen to the autoantibodies specifically found in Sjogren's syndrome and this autoantigen finds application as a prophylactic and therapeutic drug for autoimmune diseases, particularly Sjogren's syndrome, or a diagnostic agent for such diseases.

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