Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-04-15
2000-02-22
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 912, 536 231, 536 243, 5303871, 530350, C12Q 168, G01N 3353, C12P 1934, C07H 2102
Patent
active
06027896&
ABSTRACT:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
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Enghild Jan
Roses Allen D.
Salvesen Guy S.
Schmechel Donald E.
Strittmatter Warren J.
Chakrabarti Arun Kr.
Duke University
Fredman Jeffrey
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