Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1989-06-14
1991-09-03
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 27, 935 77, 935 78, C12Q 168, C07H 1512, C12N 1500
Patent
active
050454498
ABSTRACT:
Methods of determining genetic predisposition for vascular aneurysm in mammals are disclosed. The base sequence of Type III procollagen DNA of the person tested is compared to the sequence of a standard pro.alpha.l(III) sequence. Differences in the base sequence of the test DNA indicate an increased likelihood that the person will develop vascular aneurysm. Family members of the mammal tested can also be tested to determine if they also have a genetic predisposition to vascular aneurysm by testing for the presence of the mutation in the pro.alpha.l(III) gene of the family members.
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Ala-Kokko Leena M.
Baldwin Clinton T.
Kontusaari Sirpa I.
Kuivaniemi S. Helena
Prockop Darwin J.
Fleisher Mindy B.
Thomas Jefferson University
Wax Robert A.
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