Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-07-17
2007-07-17
Schnizer, Richard (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S450000, C530S350000
Reexamination Certificate
active
09330903
ABSTRACT:
Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery of ribozymes, antisense polynucleotides, and DNA and RNA expression vectors into airway epithelial cells, alveoli, pulmonary macrophages and other cells in the respiratory tract (including the oropharynx, nose, nasopharynx). These methods may be used for optimization of transfection efficiency and expression in vivo, and for in vivo expression, for example for generating an immune response, or inducing immunological tolerance.
REFERENCES:
patent: 5049389 (1991-09-01), Radhakrishnan
patent: 5333106 (1994-07-01), Lanpher
patent: 5404871 (1995-04-01), Goodman et al.
patent: 5450336 (1995-09-01), Rubsamen et al.
patent: 5458136 (1995-10-01), Jaser et al.
patent: 5474059 (1995-12-01), Cooper
patent: 5497763 (1996-03-01), Lloyd
patent: 5522385 (1996-06-01), Lloyd
patent: 5547932 (1996-08-01), Curiel et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5718222 (1998-02-01), Lloyd et al.
patent: 5724957 (1998-03-01), Rubsamen et al.
patent: 5736327 (1998-04-01), Collins
patent: 5756353 (1998-05-01), Debs
patent: 5795587 (1998-08-01), Gao et al.
patent: 5803078 (1998-09-01), Brauner
patent: 5819726 (1998-10-01), Rubsamen et al.
patent: 5823178 (1998-10-01), Lloyd et al.
patent: 5829435 (1998-11-01), Rubsamen et al.
patent: 5849719 (1998-12-01), Carson et al.
patent: 5906202 (1999-05-01), Schuster et al.
patent: 5908777 (1999-06-01), Lee et al.
patent: 5948681 (1999-09-01), Scanlin et al.
patent: 5976567 (1999-11-01), Wheeler et al.
patent: 5994314 (1999-11-01), Eljamal
patent: 5994315 (1999-11-01), Nyce et al.
patent: 6008202 (1999-12-01), Huang et al.
patent: 6030834 (2000-02-01), Chu et al.
patent: 2003/0124093 (2003-07-01), Rothenpieler et al.
patent: WO 94/27653 (1994-12-01), None
patent: WO 96/13161 (1996-05-01), None
patent: WO 96/40963 (1996-12-01), None
patent: WO 96/41873 (1996-12-01), None
Yonemitsu et. al.; HVJ (Sendai virus)-cationic liposomes: a novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium, 1997, Gene Therapy 4: 631-638.
Gagne et. al.; Aerosolization of Plasmid DNA Protective Effects of Solute, Condensing Agents, and Liposome Carriers, 1997, Proceed Int'l Symp. Control Rel. Bioact. Mater, 641-642.
Mitchell et. al.; Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes; 1995, Immunotechnology 1: 211-219.
Crook et. al.; Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation, 1996, Gene Therapy3: 834-839.
McLachlan et. al.; Evaluation in vitro and in vivo of vationic liposome-expression construct complex es for cystic fibrosis gene therapy, 1995, Gene Therapy2: 614-622.
Saravolac et al (J. Drug Targ. 7(6): 423-437, 2000).
Tang et al (Gene Therapy, 4: 823-832, 1997), abstract and Fig. 4 on p. 832).
Mack (Am. J. Med. Sci. 307(2): 138-143, 1992).
Patil et al (AAPS Journal 6(4): 1-10, 2004).
Brigham et al. (1994), “Gene Therapy for Inflammatory Diseases,”Prog. Clin. Biol. Res.,vol. 388:361-365.
Cannizzo et al. (Jun. 1997), “Augmentation of Blood Platelet Levels by Intratracheal Adminstration of an Adenovirus Vector Encoding Human Thrombopoietin cDNA,”Nature Biotechnology, vol. 15:570-573.
Canonico et al. (1994), “Aerosol and Intravenous Transfection of Human α1-Antitrypsin Gene to Lungs of Rabbots,”Am. J. Respir. Cell. Mol. Biol.,vol. 10:24-29.
Erzurum et al. (1993), “Protection of Human Endothelial Cells from Oxidant Injury by Adenovirus-Mediated Transfer of the Human Catalase cDNA,”Nucl. Acid. Res.,vol. 21(7):1607-1612.
Fujiwara et al. (Oct. 1994), “Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model,”J. Natl. Cancer Inst.,vol. 86(19):1458-1462.
Knoell et al. (1995), “Clinical Implications of Gene Therapy for Alpha1-Antitrypsin Deficiency,”Chest, vol. 107:535-545.
Kolls et al. (Mar. 1995), “Adenovirus-Mediated Blockade of Tumor Necrosis Factor in Mice Protects Against Endotoxic Shock Yet Impairs Pulmonary Host Defects,”J. Infect. Dis.,vol. 171:570-575.
McDonald et al. (Mar. 1997), “Safety of Airway Gene Transfer with Ad2/CFTR2: Aerosol Administration in the Nonhuman Primate,”Human Gene Therapy, vol. 8:411-422.
Patapoff and Gonda (1997) “Inhalation Delivery of Therapeutic Peptides and Proteins,” A. Adjei and P. Gupta, eds., Marcel Dekker, Inc., pp. 493-514.
Porteous et al. (1997,) “Evidence for Safety and Efficacy of DOTAP Cationic Liposome Mediated CFTR Gene Transfer to the Nasal Epithelium of Patients with Cystic Fibrosis,”Gene Therapy, vol. 4: 210-218.
Rosenfeld et al. (Apr. 1991), “Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo,”Science, vol. 252:431-434.
Schuster et al. (1997), “The AERxAerosol Delivery System,”Pharm. Res.,vol. 14(3):354-357.
Smith et al. (1994), “Surfactant Protein A-Directed Toxin Gene Kills Ling Cancer Cells In Vitro,”Hum. Gene Ther.,vol. 5:29-35.
Gonda Igor
Schreier Hans
Aradigm Corporation
Bozicevic Karl
Bozicevic Field & Francis LLP
Schnizer Richard
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