Methods of decreasing or preventing pain using spicamycin or der

Details Methods of decreasing or preventing pain using spicamycin or der Methods of decreasing or preventing pain using spicamycin or der

1998-01-26

1999-05-18

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K31/70

Patent

active

059050691

ABSTRACT:
Methods of providing pain relief which includes the steps of identifying an animal in need of pain relief and administering an amount of spicamycin or a derivative thereof sufficient to provide pain relief.

REFERENCES:
patent: 5461036 (1995-10-01), Otake et al.
patent: 5631238 (1997-05-01), Otake et al.
Kamishohara et al., "Antitumor Activity of SPM VIII, A Derivative of the Nucleoside Antibiotic Spicamycin, Against Human Tumor Xenografts", The Journal of Antibiotics 47:1305-1311, 1994.
Kamishohara et al., "Antitumor Activity of a Spicamycin Derivative, KRN5500, and its Active Metabolite in Tumor Cells", Oncology Research 6:383-390, 1994.
Kamishohara et al., "Inhibitory Effect of a Spicamycin Derivative, KRN5500, on the Growth of Hepatic Metastasis of Human Colon Cancer-Producing . . . ", Cancer Chemother Pharmacol 38:495-498, 1996.
Kamishohara et al., "Structure-Antitumor Activity Relationship of Semi-Synthetic Spicamycin Analogues", The Journal of Antibiotics 46:1439-1446, 1993.
Sakai et al., "Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives", The Journal of Antibiotics 48:1467-1488, 1995.
Sakai et al., "Synthesis and Antitumor Activities of Glycine-exchanged Analogs of Spicamycin", The Journal of Antibiotics 48:504-508, 1995.
Simpson et al., "Reduction in the Mechanonociceptive Response by Intrathecal Administration of Glycine and Related Compounds", Neurochemical Research 21:1221-1226, 1996.
Simpson et al., "Reduction in Thermal Hyperalgesia by Intrathecal Administration of Glycine and Related Compounds", Neurochemical Research 22:75-79, 1997.
Woolf, "The Pathophysiology of Peripheral Neuropathic Pain -- Abnormal Peripheral Input and Abnormal Central Processing", Acta Neurochir 58:125-130, 1993.

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