Methods of culturing dermal papilla cells

Details Methods of culturing dermal papilla cells Methods of culturing dermal papilla cells

2011-07-26

2011-07-26

Lankford, Leon B (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S325000, C435S352000, C435S366000, C435S375000, C435S405000

Reexamination Certificate

active

07985587

ABSTRACT:
The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.

REFERENCES:
patent: 5091173 (1992-02-01), Buultjens et al.
patent: 5208145 (1993-05-01), Rogers
patent: 5686289 (1997-11-01), Humes et al.
patent: 6159950 (2000-12-01), Crystal et al.
patent: 6485972 (2002-11-01), McMahon et al.
patent: 7067474 (2006-06-01), Birchmeier et al.
patent: 2357015 (1999-08-01), None
patent: 408066183 (1996-03-01), None
patent: WO 95/17416 (1995-06-01), None
patent: WO 97/17982 (1997-05-01), None
patent: WO 99/42481 (1999-08-01), None
patent: WO 00/31134 (2000-06-01), None
Chen et al., “Wnt Signaling to β-Catenin Involves Two Interactive Components,” J. Biol. Chem., 275:17894-99 (2000).
Cross et al., “The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf,” Biochem. J., 303:21-26 (1994).
Davies et al., “Specificity and mechanism of action of some commonly used protein kinase inhibitors,” Biochem. J., 351:95-105 (2000).
Desbois-Mouthon et al., “Insulin and IGF-1 stimulate β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation,” Oncogene, 20:252-259 (2001).
Eldar-Finkelman et al., “Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells,” J. Biol. Chem., 270:987-990 (1995).
Fang et al, “Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A,” Proc. Natl. Acad. Sci. USA, 97:11960-65 (2000).
Farr et al., “Interaction among GSK-3, GBP, Axin, and APC in Xenopus Axis Specification,” J. Cell Biol., 148:691-701 (2000).
Frame et al., “GSK3 takes centre stage more than 20 years after its discovery,” Biochem. J., 359:1-16 (2000).
Hedgepeth et al., “Regulation of Glycogen Synthase Kinase 3β and Downstream Wnt Signaling by Axin,” Mol. Cell. Biol., 19:7147-57 (1999).
Klein et al., “A molecular mechanism for the effect of lithium on development,” Proc. Natl. Acad. Sci. USA, 93:8455-59 (1996).
Leclerc et al., “Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease,” J. Biol. Chem., 276:251-260 (2001).
Leost et al., “Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-depedent kinase 5/p25,” Eur. J. Biochem., 267:5983-94 (2000).
Meijer et al., “Pharmacological inhibitors of glycogen synthase kinase 3,” Trends Pharm. Sci., 25:1-10 (2004).
Moule et al., “Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells,” J. Biol. Chem., 272:7713-19 (1997).
Saito et al., “The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells,” Biochem. J., 303:27-31 (1994).
Stambolic et al., “Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation,” Biochem. J., 303:701-704 (1994).
Sutherland et al., “Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signaling,” Biochem. J., 296:15-19 (1993).
Arias et al., “Wnt signaling: pathway or network?”, Aug. 1999, Curr.Opin.Genet.Dev., vol. 9, No. 4;447-54.
Charpentier et al., “Plakoglobin Suppresses Epithelial Proliferation and Hair Growth In Vivo”, Apr. 17, 2000, J. Cell Biol., vol. 149, No. 2;503-519.
Christiansen et al., “Murine Wnt-11 and Wnt-12 have temorally . . . ”, Jun. 1995, Mech.Dev., vol. 51, No. 2,3;341-50.
Chuong et al., “Early Events During Avian Skin Appendage Regeneration: . . . ”, 1996, J. Invest. Dermatol., vol. 107;639-646.
DasGupta et al., “Multiple roles for activated LEF/TCF transcription complexes . . . ”, Development, vol. 126, Oct. 1999;4557-4568.
Gat et al., “De Novo Hair Follicle Morphogenesis and Hair Tumors . . . ”, Cell, vol. 95, Nov. 25, 1998;605-614.
Gavin et al., “Expression of mutiple novel Wnt-1/int-1-related . . . ”, Dec. 1990, Genes Dev., vol. 4, No. 12b;2319-2332.
Genderen et al., “Development of several organs that require inductive epithial . . . ”, Genes & Develpoment, vol. 8, No. 22, Nov. 15, 1994;2691-2703.
Goodrich et al., “Conservation of the hedgehog/patched . . . ”, Feb. 1996, 90Genes Dev., vol. 10, No. 3;301-12.
Hardy, “The secret life of the hair follicle”, 1992, Trends in Genetics, vol. 8;55-61.
Kengaku et al., “Distinct WNT pathways regulating AER . . . ”, May 1998, Science, vol. 280;1274-1277.
Kishimoto et al., “Selective activation of the versican . . . ”, Jun. 1999, Proc.Natl. Acad.Sci. USA, vol. 96, No. 13.
Kishimoto et al., “Wnt signaling maintains the hair-inducing activity of the dermal papilla”, 2000, vol. 14;1181-1185.
Lee et al., “Insertional mutagenesis identifies a member of the Wnt . . . ”, Mar. 1995, Proc.Natl.Acad.Sci. USA, vol. 92, No. 6;2268-2272.
Marigo et al., “Conservation in hedgehog signaling . . . ”, Apr. 1996, Development, vol. 122, No. 4;1225-1233.
Millar et al., “WNT Signaling in the Control of Hair Growth and Structure”, Development Biology, vol. 207, No. 1, Mar. 1, 1999;133-149.
Noramly et al., “β-catenin signaling can initiate feather bud development”, Development, vol. 126, Aug. 1999;3509-3521.
Nusse et al., “Wnt Genes”, Cell, vol. 69, Jun. 26, 1992;1073-1087.
Oro et al., “Splitting Hairs: Dissecting Roles of Sighnaling Systems in Epideraml Development”, Cell, vol. 95, Nov. 25, 1998;575-578.
Pennisi, “Hairy Mice Offer Hope for Baldness Remedy”, Science, vol. 282, Nov. 27, 1998; 1617-1619.
Riddle et al., “Induction of the LIM homeobox gene . . . ”, Nov. 1995, Cell, vol. 83, No. 4;631-640.
Sato et al., “Induction of hair growth phase . . . ”, Oct. 1999, J.Clin.Invest., vol. 104, No. 7;855-864.
St. Jacques et al., “Sonic hedgehog signaling . . . ”, Sep. 1998, Curr.Biol., vol. 8, No. 19;1058-1068.
Veer et al., “Molecular cloning and chromosomal . . . ”, Nov. 1984, Mol.Cell Biol., vol. 4, No. 11;2532-2534.
Wainwright et al., “Isolation of a human gene with protein sequence . . . ”, 1988, vol. 7, No. 6;1743-1748.
International Search Report, Jul. 27, 2001.

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