Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-02-18
1999-05-04
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
6048901, 6048911, 424422, 424423, 424424, 424425, A61K 3173, A61K 922, A61F 1300
Patent
active
059004088
ABSTRACT:
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3.5 kDa to 250 kDa and preferably about 3.5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization. The layer of the chitosan-drug complex is characterized by a prolonged drug time release property as compared with complexes made from polymerized chitosan. A corresponding method of providing drug delivery to the locale of the implant within a patient is disclosed as is the implant.
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Block Lawrence H.
Sabnis Shobhan S.
Duquesne University of the Holy Ghost
Fonda Kathleen K.
Silverman Arnold B.
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