Methods of controlling the concentration of calcium in the serum

Details Methods of controlling the concentration of calcium in the serum Methods of controlling the concentration of calcium in the serum

1982-12-29

1985-04-16

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

045115648

ABSTRACT:
The present invention relates to a method of controlling the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D.sub.3 -26,23-lactones expressed by the following formula (I) ##STR1## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--, to warm-blooded animals, and a pharmaceutical composition to be used for controlling the concentration of calcium in the serum of warm-blooded animals which comprises 25-hydroxyvitamin D.sub.3 -26,23-lactones expressed by the above-mentioned formula (I) and a pharmaceutically acceptable carrier.
25-hydroxyvitamin D.sub.3 -26,23-lactones are desirably used especially for the treatment or prevention of the diseases resulting from the high calcium levels in the serum.

REFERENCES:
patent: 4307231 (1980-07-01), DeLuca et al.
patent: 4336193 (1982-06-01), DeLuca et al.
Tanaka et al., Proc. Natl. Acad. Sci., vol. 77, No. 11, pp. 6411-6414, (1980), "Role of Kidney Tissue in the Production of 25-Hydroxyvit-D.sub.3 -26,23-Lactone and 1.alpha.,25-dihydroxyvitamin D.sub.3 -26,23-Lactone".
FEBS Lett. (1982) 139(2), pp. 267-270, as shown in Chem. Abstract vol. 96(23), Par. 198, 337(p).

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