Methods of constructing and screening diverse expression...

Details Methods of constructing and screening diverse expression... Methods of constructing and screening diverse expression...

2007-09-18

2007-09-18

Wessendorf, T. D. (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C435S007800, C435S007320, C435S007330, C435S007340, C435S007350, C435S243000, C435S091500, C435S091500, C435S091500

Reexamination Certificate

active

10372003

ABSTRACT:
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the libraries are derived from two or more diverse characterized genomes.

REFERENCES:
patent: 5516637 (1996-05-01), Huang et al.
patent: 5763239 (1998-06-01), Short et al.
patent: 5783431 (1998-07-01), Peterson et al.
patent: 5821047 (1998-10-01), Garrard et al.
patent: 6083715 (2000-07-01), Georgiou et al.
patent: 6174673 (2001-01-01), Short et al.
patent: 6190908 (2001-02-01), Kang
patent: 6238884 (2001-05-01), Short et al.
patent: 6297004 (2001-10-01), Russell et al.
patent: 6316223 (2001-11-01), Payan et al.
patent: 6319690 (2001-11-01), Little et al.
patent: 6361969 (2002-03-01), Galeotti
patent: 6579675 (2003-06-01), Kamb
patent: 6583275 (2003-06-01), Doucette-Stamm et al.
patent: 6720139 (2004-04-01), Zyskind et al.
patent: 2002/0150906 (2002-10-01), Debe
patent: WO95/17412 (1995-06-01), None
patent: WO98/16835 (1998-04-01), None
patent: WO99/35282 (1999-07-01), None
patent: WO-2006/017913 (2006-02-01), None
Amann et al., “ATG vectors'for regulated high-level expression of cloned genes inEscherichia coli,” Gene (1985), 40:183-190.
Balaban et al., “Autoinducer of virulence as a target for vaccine and therapy againstStaphylococcus aureus,” Science, (1998), 280:438-440.
Baud et al., “Measures of residue density in protein structures,” PNAS (1999) 96: 12494-12499.
Berzofsky, Jay A., “Intrinsic and extrinsic factors in protein antigen structure.” Science, (1995) 229:932-940.
Blum et al., “Isolation of peptide aptamers that inhibit intracellular processes,” PNAS (2000) 97:2241-2246.
Bonaldo et al., “Normalization and subtraction: two approaches to facilitate gene discovery,” Genome Research (1996) 6:791-806.
Bremnes et al., “Selection of phage displayed peptides from a random 10-mer library recognising a peptide target,” Immunotechnology (1998) 4:21-28.
Britten et al., “Repeated sequence in DNA,” Science (1968) 161:529-540.
Burioni et al., “A new subtraction technique for molecular cloning of rare antiviral antibody specificaties from phage display libraries,” Res. Virol. (1998) 149:327-330.
Campbell et al., “Solution secondary structure of a bacterially expressed peptide from the receptor binding domain of pseudomonas aeruginosa pill strain pak: a heteronuclear multidimensional nmr study,” Biochemistry (1997) 36:12791-12801.
Caponigro et al., “Transdominant genetic analysis of a growth control pathway,” PNAS USA, (1998) 95:7508-7513.
Chapman et al., “Recognition of twoDermatophagoides pteronyssinus-specific epitopes on antigen p1by using monoclonal antibodies: binding to each epitope can be inhibited by serum from dust mite-allergic patients,” Journal of Immunology (1984) 133: 2488-2495.
Colas et al., “Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2,” Nature, (1996) 380:548-550.
Colbere-Garapin et al., “A new dominant hybrid selective marker for higher eukaryotic cells,” J. Mol. Biol. (1981) 150:1-14.
De Soultrait et al., “A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase,” J. Mol. Biol. (2002) 318:45-58.
Dent et al., “The genetics of ivermectin resistance inCaenorhabditis elegans,” PNAS USA, (2000), 97:2674-2679.
Derossi et al., “The third helix of the antennapedia homeodomain translocates through biological membranes,” Journal of Biological Chemistry (1994) 269:10444-10450.
Devereaux et al. “A comprehensive set of sequence analysis programs for the VAX,” Nucleic Acids Research (1984) 12: 387-395.
DeVito et al., “An array of target-specific screening strains for antibacterial discovery,” Nature Biotechnology (2002) 20:478-483.
Faber et al., “Polyglutamine-mediated dysfunction and apoptotic death of a caenorhabiditis elegans sensory neuron,” PNAS USA (1999) 96:179-184.
Fabret et al., “Efficient gene targeted random mutagenesis in genetically stableEscherichia colistrains,” Nucleic Acids Research (2000) 28: 5 pages.
Fahraeus et al., Inhibition of prb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16cdkn2/ink4an, Current Biology (1996) 6:84-91.
Fehrsen et al., “Cross-reactive epitope mimics in a fragmented-genome phage display library derived from the rickettsia,Cowdria ruminantium”, Immunotechnology (1999) 4:175-184.
FitzGerald, K., “In vitro display technologies—new tools for drug discovery,” DDT (2000) 5:253-258.
Franzoni et al., “Structure of the C-terminal fragment 300-320 of the rat angiotensin II AT1areceptor and its relevance with respect to G-protein coupling,” Journal of Biological Chemistry (1997) 272:9734-9741.
Gegg et al., “Probing minimal independent folding units in dihydrofolate reductase by molecular dissection,” Protein Science (1997) 6:1885-1892.
Getzoff et al., “Mechanisms of antibody binding to a protein,” Science (1987) 235:1191-1196.
Greene et al., “IgE binding structures of the major house dust mite allergenDER PI,” Molecular Immunology (1992) 29:257-262.
Hengeveld et al., “Functional and structural characterization of a synthetic peptide representing the N-terminal domain of prokaryotic pyruvate dehydrogenase,” Biochemistry (2002) 41:7490-7500.
Heymarin et al., “Antigenic and structural analysis of group II allergens (Derf II andDerp II) from house dust mites (Dermatophagoidesspp),” J. Allergy Clin. Immunol. (1989) 83:1055-1067.
Hofmann et al., “Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette,” PNAS USA, (1996) 93:5185-5190.
Hoogenboom et al., “Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains,” Nucleic Acids Research (1991) 19:4133-4137.
Horng et al., “Characterization of large peptide fragments derived from the N-terminal domain of the ribosomal protein L9: definition of the minimum folding motif and characterization of local electrostatic interactions,” Biochemistry (2002) 41:13360-13369.
Houshmand et al., “Use of bacteriophage T7 displayed peptides for determination of monoclonal antibody specificity and biosensor analysis of the binding reaction,” Analytical Biochemistry (1999) 268:363-370.
Humphrey et al., “Chemical synthesis of natural product peptides; coupling methods for the incorporation of noncoded amino acids into peptides,” Chem. Rev. (1997) 97:2243-2266.
Irback et al., “Evidence for nonrandom hydrophobicity structures in protein chains,” PNAS USA (1996) 93:9533-9538.
Kinzler et al., “Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins,” Nucleic Acids Research (1989) 17:3645-3653.
Kolonin et al., “Targeting cyclin-dependent kinases inDrosophilawith peptide aptamers,” PNAS USA (1998) 95:14266-14271.
Koncz et al., “Expression and assembly of functional bacterial luciferase in plants,” PNAS USA (1987) 84:131-135.
Kopczynski et al., “A high throughput screen to identify secreted and transmembrane proteins involved inDrosophilaembryogenesis,” PNAS USA (1998) 95: 9973-9978.
Lee et al., “Structure-antigenicity relationship of peptides from the pre-s2 region of the hepatitis B virus surface antigen,” Biochemistry and Molecular Biology International (1994) 34:159-168.
Leitner et al., “A mimotope defined by phage display inhibits IgE binding to the plant panallergen profilin,” Eur. J. Immunol. (1998) 28:2921-2927.
Lesley et al., 

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