Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1990-09-11
1992-10-13
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530323, 530345, 5303917, 5303919, 530399, 530404, 530405, 530408, 530409, 424 8591, C07K 512, C07K 1702, A61K 3944
Patent
active
051552108
ABSTRACT:
The invention provides for antinomycin D derivatives and methods of producing antinomycin D derivatives. Such derivatives include isocyanate, thioisocyanate, carboxylic acid, bromide, aldehyde and sulfonic acid derivatives. The invention also provides for actinomycin D derivatives conjugated to target cell binding proteins. Methods are provided to make such conjugates through attachment of the derivatized moiety to a reactive group on a target cell binding protein or on a spacer. The conjugates can be administered to an animal and produce localized cytotoxic effects on target cells.
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Brunswick Corporation
Kim Kay K.
Nucker Christine M.
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